CIT and RND3

Data Source:
BioGRID (two hybrid)

		CIT	RND3
Description		citron rho-interacting serine/threonine kinase	Rho family GTPase 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Membrane	Golgi Membrane Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Coactivator Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding SH3 Domain Binding Protein Kinase Binding PDZ Domain Binding Protein Serine/threonine Kinase Inhibitor Activity Metal Ion Binding Scaffold Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Mitotic Cell Cycle Mitotic Cytokinesis Peptidyl-threonine Phosphorylation Actomyosin Structure Organization Positive Regulation Of Cytokinesis Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Generation Of Neurons Neuron Apoptotic Process Negative Regulation Of Protein Serine/threonine Kinase Activity	Actin Filament Organization Cell Adhesion Establishment Or Maintenance Of Cell Polarity Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Cell Migration Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization
Pathways		RHO GTPases activate CIT RHO GTPases activate CIT
Drugs		Fostamatinib	Guanosine-5'-Triphosphate
Diseases
GWAS		Number of sexual partners ( 30643258) Urgency urinary incontinence ( 25524241)	Arterial stiffness (brachial-ankle pulse wave velocity) ( 32790701) Endometriosis ( 23472165) Esophageal adenocarcinoma x gastroesophageal reflux disease interaction ( 29551738) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Neonatal total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Platelet count ( 31217584) Reticulocyte fraction of red cells ( 32888494) Type 2 diabetes ( 22238593) Urinary metabolite levels in chronic kidney disease ( 29545352)
Interacting Genes		10 interacting genes: DISC1 DLG4 GRIN1 GRIN2D MTNR1A RAC1 RHOA RHOB RHOC RND3	8 interacting genes: ARHGAP5 C14orf119 CIT CPLANE2 PLXNB1 ROCK1 SKP2 UBXN11
Entrez ID		11113	390
HPRD ID		09289	04233
Ensembl ID		ENSG00000122966	ENSG00000115963
Uniprot IDs		O14578	B2R838 P61587
PDB IDs			1M7B 2V55 4BG6
Enriched GO Terms of Interacting Partners?
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