BLOC1S5 and LRRK1

Data Source:
BioGRID (pull down)

		BLOC1S5	LRRK1
Description		biogenesis of lysosomal organelles complex 1 subunit 5	leucine rich repeat kinase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Transport Vesicle BLOC-1 Complex Axon Cytoplasm	Cytoplasm Mitochondrion Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	Protein Serine/threonine Phosphatase Activity Protein Binding ATP Binding GTP Binding Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Anterograde Axonal Transport Neuron Projection Development Melanosome Transport Melanosome Organization Endosome To Melanosome Transport Anterograde Synaptic Vesicle Transport Positive Regulation Of Pigment Cell Differentiation	Protein Phosphorylation Protein Dephosphorylation Signal Transduction Osteoclast Development Bone Resorption Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Signal Transduction
Pathways
Drugs
Diseases
GWAS		Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261)	Central corneal thickness ( 32528159 28171582 31798171 29760442) Corneal structure ( 23291589) Height ( 28552196)
Interacting Genes		15 interacting genes: ABI2 ABI3 APP BLOC1S1 BLOC1S2 BLOC1S4 DTNBP1 HSBP1 LRRK1 OIP5 PBX2 PKNOX1 SMARCD1 SNAPIN TSNAX	51 interacting genes: ABL1 BAG1 BAG2 BAG3 BAG5 BLOC1S5 C11orf52 CBLB CCL21 CD2BP2 CDC42EP3 CHGB CKAP2 CLVS1 CPLX3 CWC15 ECHS1 EGFR ENKUR EPHA8 FAM184A FBXL14 FGFR2 FLT4 FOXP1 GAK GNAZ GPBP1L1 ITCH KIF20A MATK MTG1 NEK1 NUDT16L1 ODF2 PAK6 PDCD4 PLK1 POLR2M RAB29 RET SCEL SH2D2A SNX21 SNX9 STUB1 TCF25 TEC TEX33 TIRAP VGLL4
Entrez ID		63915	79705
HPRD ID		06289	14319
Ensembl ID		ENSG00000188428	ENSG00000154237
Uniprot IDs		A0A0A0MTN6 Q8TDH9	Q38SD2
PDB IDs
Enriched GO Terms of Interacting Partners?
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