LRRK1 and MATK

Data Source:
BioGRID (pull down)

		LRRK1	MATK
Description		leucine rich repeat kinase 1	megakaryocyte-associated tyrosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Intracellular Membrane-bounded Organelle	Cytosol Membrane
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding ATP Binding GTP Binding Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Protein Phosphorylation Protein Dephosphorylation Signal Transduction Osteoclast Development Bone Resorption Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Signal Transduction	Protein Phosphorylation Positive Regulation Of Cell Population Proliferation Peptidyl-tyrosine Phosphorylation ERBB2 Signaling Pathway
Pathways			Downregulation of ERBB2 signaling
Drugs			Fostamatinib
Diseases
GWAS		Central corneal thickness ( 32528159 28171582 31798171 29760442) Corneal structure ( 23291589) Height ( 28552196)	Obesity-related traits ( 23251661)
Interacting Genes		51 interacting genes: ABL1 BAG1 BAG2 BAG3 BAG5 BLOC1S5 C11orf52 CBLB CCL21 CD2BP2 CDC42EP3 CHGB CKAP2 CLVS1 CPLX3 CWC15 ECHS1 EGFR ENKUR EPHA8 FAM184A FBXL14 FGFR2 FLT4 FOXP1 GAK GNAZ GPBP1L1 ITCH KIF20A MATK MTG1 NEK1 NUDT16L1 ODF2 PAK6 PDCD4 PLK1 POLR2M RAB29 RET SCEL SH2D2A SNX21 SNX9 STUB1 TCF25 TEC TEX33 TIRAP VGLL4	24 interacting genes: AKT1 AR CACNA1A CD36 ERBB2 ERBB3 ERBB4 EWSR1 FRS3 HSPA5 HSPA9 ILK KIT LRRK1 LRRK2 LYN MET NTRK1 PTK2B PTPRD PXN SIRPA SMURF1 SRC
Entrez ID		79705	4145
HPRD ID		14319	02496
Ensembl ID		ENSG00000154237	ENSG00000007264
Uniprot IDs		Q38SD2	F1T0G6 P42679
PDB IDs			1JWO 1X6G 3US4
Enriched GO Terms of Interacting Partners?
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