LRRK1 and CD2BP2

Data Source:
BioGRID (pull down)

		LRRK1	CD2BP2
Description		leucine rich repeat kinase 1	CD2 cytoplasmic tail binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Intracellular Membrane-bounded Organelle	Fibrillar Center Nucleus Nucleoplasm U5 SnRNP Cytoplasm Cytosol Nuclear Speck U4/U6 X U5 Tri-snRNP Complex
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding ATP Binding GTP Binding Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Protein Phosphorylation Protein Dephosphorylation Signal Transduction Osteoclast Development Bone Resorption Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Signal Transduction	Spliceosomal Tri-snRNP Complex Assembly MRNA Splicing, Via Spliceosome Negative Regulation Of Phosphatase Activity
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Central corneal thickness ( 32528159 28171582 31798171 29760442) Corneal structure ( 23291589) Height ( 28552196)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		51 interacting genes: ABL1 BAG1 BAG2 BAG3 BAG5 BLOC1S5 C11orf52 CBLB CCL21 CD2BP2 CDC42EP3 CHGB CKAP2 CLVS1 CPLX3 CWC15 ECHS1 EGFR ENKUR EPHA8 FAM184A FBXL14 FGFR2 FLT4 FOXP1 GAK GNAZ GPBP1L1 ITCH KIF20A MATK MTG1 NEK1 NUDT16L1 ODF2 PAK6 PDCD4 PLK1 POLR2M RAB29 RET SCEL SH2D2A SNX21 SNX9 STUB1 TCF25 TEC TEX33 TIRAP VGLL4	14 interacting genes: ACAD11 AKNA CD2 CHRM3 CSNK2A1 LRRK1 PRPF6 PSMF1 SMU1 SNRPB TRAPPC6A TXNL4A WBP11 ZNHIT2
Entrez ID		79705	10421
HPRD ID		14319	05127
Ensembl ID		ENSG00000154237	ENSG00000169217
Uniprot IDs		Q38SD2	A0A024QZC1 O95400
PDB IDs			1GYF 1L2Z 1SYX 4BWS
Enriched GO Terms of Interacting Partners?
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