SAA1 and LAMA1

Data Source:
HPRD (in vitro)

		SAA1	LAMA1
Description		serum amyloid A1	laminin subunit alpha 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasmic Microtubule High-density Lipoprotein Particle Extracellular Exosome Endocytic Vesicle Lumen	Extracellular Region Basement Membrane Laminin-1 Complex Laminin-3 Complex Extracellular Space Cell-cell Junction Membrane Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	G Protein-coupled Receptor Binding Heparin Binding	Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Protein C-terminus Binding Glycosphingolipid Binding
	Biological Process	Activation Of MAPK Activity Positive Regulation Of Cytokine Production Receptor-mediated Endocytosis Acute-phase Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cytokine-mediated Signaling Pathway Platelet Activation Neutrophil Chemotaxis Positive Regulation Of Interleukin-1 Production Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Cell Adhesion Macrophage Chemotaxis Lymphocyte Chemotaxis Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response	Morphogenesis Of An Epithelial Sheet Protein Phosphorylation Cell Adhesion Cell Surface Receptor Signaling Pathway Axon Guidance Animal Organ Morphogenesis Tissue Development Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Camera-type Eye Development Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Embryonic Development Blood Vessel Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Retinal Blood Vessel Morphogenesis
Pathways		Scavenging by Class B Receptors G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-4 and Interleukin-13 signaling Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation Amyloid fiber formation	Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions MET activates PTK2 signaling
Drugs			Lanoteplase
Diseases
GWAS		Amyloid A serum levels ( 21124955) Blood protein levels ( 30072576 29875488 28240269) Rosacea symptom severity ( 29771307)	Adverse response to drug ( 30420678) Response to citalopram treatment ( 22760553) Type 2 diabetes ( 30054458 22693455 30297969 32499647)
Interacting Genes		9 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 FPR1 GLP1R LAMA1 SELENOS VKORC1	20 interacting genes: ACHE APCS APP C3 COL7A1 DAG1 FBLN2 HSPG2 ITGA1 ITGA2 ITGB1 MEP1A NID1 NT5E PLAT PLG SAA1 SAA2 TMPRSS6 UBC
Entrez ID		6288	284217
HPRD ID		00097	01033
Ensembl ID		ENSG00000173432	ENSG00000101680
Uniprot IDs		P0DJI8	P25391
PDB IDs		4IP8 4IP9 6MST
Enriched GO Terms of Interacting Partners?
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