LAMA1 and HSPG2

Data Source:
HPRD (in vitro)

		LAMA1	HSPG2
Description		laminin subunit alpha 1	heparan sulfate proteoglycan 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-1 Complex Laminin-3 Complex Extracellular Space Cell-cell Junction Membrane Extracellular Matrix Collagen-containing Extracellular Matrix	Extracellular Region Basement Membrane Extracellular Space Golgi Lumen Plasma Membrane Focal Adhesion Lysosomal Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Plasma Membrane Protein Complex
	Molecular Function	Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Protein C-terminus Binding Glycosphingolipid Binding	Amyloid-beta Binding Calcium Ion Binding Protein Binding Protein C-terminus Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Morphogenesis Of An Epithelial Sheet Protein Phosphorylation Cell Adhesion Cell Surface Receptor Signaling Pathway Axon Guidance Animal Organ Morphogenesis Tissue Development Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Camera-type Eye Development Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Embryonic Development Blood Vessel Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Retinal Blood Vessel Morphogenesis	Retinoid Metabolic Process Angiogenesis Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Lipid Metabolic Process Receptor-mediated Endocytosis Inflammatory Response Brain Development Animal Organ Morphogenesis Tissue Development Negative Regulation Of Angiogenesis Cell Differentiation Extracellular Matrix Organization Cellular Protein Metabolic Process Circulatory System Development
Pathways		Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions MET activates PTK2 signaling	Degradation of the extracellular matrix Degradation of the extracellular matrix A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Integrin cell surface interactions Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Non-integrin membrane-ECM interactions ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport Amyloid fiber formation
Drugs		Lanoteplase	Palifermin
Diseases			Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Adverse response to drug ( 30420678) Response to citalopram treatment ( 22760553) Type 2 diabetes ( 30054458 22693455 30297969 32499647)	Atrial fibrillation ( 30061737) Height ( 28552196) PR interval ( 32439900)
Interacting Genes		20 interacting genes: ACHE APCS APP C3 COL7A1 DAG1 FBLN2 HSPG2 ITGA1 ITGA2 ITGB1 MEP1A NID1 NT5E PLAT PLG SAA1 SAA2 TMPRSS6 UBC	32 interacting genes: APP ATF7IP ATN1 BMP1 CACNA1A CCN2 COL13A1 ECM1 FBLN1 FBLN2 FBN1 FGF2 FGF7 FGFBP1 FN1 GFI1B GRN ITGA2 ITGB1 LAMA1 MTDH NID1 NID2 PDGFA PDGFB PRELP PRPF40A SPARC TCAP TTR UBC VWA1
Entrez ID		284217	3339
HPRD ID		01033	00804
Ensembl ID		ENSG00000101680	ENSG00000142798
Uniprot IDs		P25391	P98160
PDB IDs			3SH4 3SH5
Enriched GO Terms of Interacting Partners?
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