SAA1 and COL4A3

Data Source:
HPRD (in vitro)

		SAA1	COL4A3
Description		serum amyloid A1	collagen type IV alpha 3 chain
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GO Annotations	Cellular Component	Extracellular Region Cytoplasmic Microtubule High-density Lipoprotein Particle Extracellular Exosome Endocytic Vesicle Lumen	Extracellular Region Collagen Type IV Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Extracellular Matrix Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix
	Molecular Function	G Protein-coupled Receptor Binding Heparin Binding	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Metalloendopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Activation Of MAPK Activity Positive Regulation Of Cytokine Production Receptor-mediated Endocytosis Acute-phase Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cytokine-mediated Signaling Pathway Platelet Activation Neutrophil Chemotaxis Positive Regulation Of Interleukin-1 Production Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Cell Adhesion Macrophage Chemotaxis Lymphocyte Chemotaxis Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Adhesion Cell Surface Receptor Signaling Pathway Sensory Perception Of Sound Blood Circulation Negative Regulation Of Cell Population Proliferation Response To Glucose Negative Regulation Of Endopeptidase Activity Negative Regulation Of Angiogenesis Extracellular Matrix Organization Glomerular Basement Membrane Development Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Endothelial Cell Apoptotic Process Negative Regulation Of Vascular Endothelial Cell Proliferation
Pathways		Scavenging by Class B Receptors G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-4 and Interleukin-13 signaling Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation Amyloid fiber formation	Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization
Drugs
Diseases			Benign familial hematuria; Thin basement membrane nephropathy Alport syndrome
GWAS		Amyloid A serum levels ( 21124955) Blood protein levels ( 30072576 29875488 28240269) Rosacea symptom severity ( 29771307)	Advanced age-related macular degeneration ( 26691988) Central corneal thickness ( 32528159 31798171 29760442) Corneal structure ( 23291589) Diabetic nephropathy in type 1 diabetes ( 31537649) Hematuria ( 30476138) Hematuria (moderate to severe) ( 30476138) Intraocular pressure ( 29235454) Kidney disease (end stage renal disease or albuminuria) in type 1 diabetes ( 31537649) Kidney disease (reduced eGFR and albuminuria or end stage renal disease) in type 1 diabetes ( 31537649) Macroalbuminuria in type 1 diabetes ( 31537649) Macular thickness ( 30535121) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Refractive error ( 32231278) Resting heart rate ( 27798624)
Interacting Genes		9 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 FPR1 GLP1R LAMA1 SELENOS VKORC1	17 interacting genes: ANTXR2 APP CAMK2B CD93 CERT1 DCN FBLN2 FN1 HABP2 MATN2 MFAP2 MMP9 OSM SAA1 SERPINE2 TGFBI USH2A
Entrez ID		6288	1285
HPRD ID		00097	00354
Ensembl ID		ENSG00000173432	ENSG00000169031
Uniprot IDs		P0DJI8	Q01955
PDB IDs		4IP8 4IP9 6MST	5NB0
Enriched GO Terms of Interacting Partners?
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