COL4A3 and CAMK2B

Data Source:
HPRD (in vitro)

		COL4A3	CAMK2B
Description		collagen type IV alpha 3 chain	calcium/calmodulin dependent protein kinase II beta
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GO Annotations	Cellular Component	Extracellular Region Collagen Type IV Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Extracellular Matrix Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix	Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Neuron Projection Synapse
	Molecular Function	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Metalloendopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength	Actin Binding Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Adhesion Cell Surface Receptor Signaling Pathway Sensory Perception Of Sound Blood Circulation Negative Regulation Of Cell Population Proliferation Response To Glucose Negative Regulation Of Endopeptidase Activity Negative Regulation Of Angiogenesis Extracellular Matrix Organization Glomerular Basement Membrane Development Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Endothelial Cell Apoptotic Process Negative Regulation Of Vascular Endothelial Cell Proliferation	Protein Phosphorylation Signal Transduction Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Protein Autophosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synapse Structural Plasticity Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Regulation Of Dendritic Spine Development Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Synapse Maturation Regulation Of Cellular Response To Heat Regulation Of Neuron Migration
Pathways		Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization	CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			[4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile Fostamatinib
Diseases		Benign familial hematuria; Thin basement membrane nephropathy Alport syndrome
GWAS		Advanced age-related macular degeneration ( 26691988) Central corneal thickness ( 32528159 31798171 29760442) Corneal structure ( 23291589) Diabetic nephropathy in type 1 diabetes ( 31537649) Hematuria ( 30476138) Hematuria (moderate to severe) ( 30476138) Intraocular pressure ( 29235454) Kidney disease (end stage renal disease or albuminuria) in type 1 diabetes ( 31537649) Kidney disease (reduced eGFR and albuminuria or end stage renal disease) in type 1 diabetes ( 31537649) Macroalbuminuria in type 1 diabetes ( 31537649) Macular thickness ( 30535121) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Refractive error ( 32231278) Resting heart rate ( 27798624)	Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Intracranial aneurysm ( 29531279) Metabolic syndrome ( 22399527) Osteoarthritis (hip) ( 23989986) Systolic blood pressure ( 30578418) Triglyceride levels ( 32203549)
Interacting Genes		17 interacting genes: ANTXR2 APP CAMK2B CD93 CERT1 DCN FBLN2 FN1 HABP2 MATN2 MFAP2 MMP9 OSM SAA1 SERPINE2 TGFBI USH2A	56 interacting genes: ACOT7 ACTN4 AP5B1 ARSA ATXN1 CAMK2A CAMK2D CAMK2G CAMK2N2 CCM2L CDC37 COL4A3 DUS1L ETS1 FAM171A2 GAPDH GRIN2A GRIN2B ITPKA KRT86 KRTAP1-1 KRTAP10-11 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-2 KRTAP6-3 MAD2L2 MED18 MEOX2 MGAT5B MORF4L1 MORF4L2 MRPL11 MVP PHKB PLCB3 PNKP POLR3C POP5 RAP2B RBFOX2 RBPMS RNF4 RPL11 RXRG SEMA4G SMYD3 SPRYD7 THRB TNPO2 TNPO3 TTC5 YWHAB ZBTB32 ZMYM5
Entrez ID		1285	816
HPRD ID		00354	12127
Ensembl ID		ENSG00000169031	ENSG00000058404
Uniprot IDs		Q01955	A4D2J9 B7Z1Z6 Q13554
PDB IDs		5NB0	3BHH
Enriched GO Terms of Interacting Partners?
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