RPE65 and RBP4

Data Source:
HPRD (in vitro)

		RPE65	RBP4
Description		retinoid isomerohydrolase RPE65	retinol binding protein 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Membrane Plasma Membrane Membrane Cell Body	Extracellular Region Extracellular Space Cytosol Protein-containing Complex Extracellular Exosome
	Molecular Function	Phosphatidylserine Binding Retinal Isomerase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Isomerase Activity Phosphatidylcholine Binding Metal Ion Binding Retinol Isomerase Activity All-trans-retinyl-palmitate Hydrolase, 11-cis Retinol Forming Activity All-trans-retinyl-ester Hydrolase, 11-cis Retinol Forming Activity Cardiolipin Binding	Protein Binding Retinal Binding Retinol Binding Retinol Transmembrane Transporter Activity Protein-containing Complex Binding
	Biological Process	Retinoid Metabolic Process Retina Homeostasis Neural Retina Development Vitamin A Metabolic Process Visual Perception Circadian Rhythm Insulin Receptor Signaling Pathway Regulation Of Gene Expression Retinol Metabolic Process Retinal Metabolic Process Detection Of Light Stimulus Involved In Visual Perception Retina Morphogenesis In Camera-type Eye Cellular Response To Electrical Stimulus Zeaxanthin Biosynthetic Process	Retinoid Metabolic Process Eye Development Positive Regulation Of Immunoglobulin Production Gluconeogenesis Heart Development Visual Perception Maintenance Of Gastrointestinal Epithelium Lung Development Positive Regulation Of Insulin Secretion Response To Retinoic Acid Retinol Transport Retinol Metabolic Process Glucose Homeostasis Response To Ethanol Embryonic Organ Morphogenesis Embryonic Skeletal System Development Cardiac Muscle Tissue Development Female Genitalia Morphogenesis Negative Regulation Of Cardiac Muscle Cell Proliferation Embryonic Retina Morphogenesis In Camera-type Eye Uterus Development Vagina Development Urinary Bladder Development Heart Trabecula Formation
Pathways		The canonical retinoid cycle in rods (twilight vision)	Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) Retinoid metabolism disease events Retinoid metabolism and transport
Drugs		Voretigene neparvovec	Tretinoin
Diseases		Leber congenital amaurosis (LCR) Retinitis pigmentosa (RP)
GWAS		Facial morphology ( 31763980) Mortality in sepsis ( 27639821) Vertical cup-disc ratio ( 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Blood protein levels ( 30072576) Optic disc area ( 31798171) Retinol levels ( 21878437)
Interacting Genes		2 interacting genes: RBP4 SLC27A1	6 interacting genes: ALB GRB2 LAMTOR5 RBBP6 RPE65 TTR
Entrez ID		6121	5950
HPRD ID		01569	01580
Ensembl ID		ENSG00000116745	ENSG00000138207
Uniprot IDs		Q16518	P02753 Q5VY30
PDB IDs			1BRP 1BRQ 1JYD 1JYJ 1QAB 1RBP 1RLB 2WQ9 2WQA 2WR6 3BSZ 3FMZ 4O9S 4PSQ 5NTY 5NU2 5NU6 5NU7 5NU8 5NU9 5NUA 5NUB 6QBA
Enriched GO Terms of Interacting Partners?
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