RBP4 and LAMTOR5

Data Source:
BioGRID (two hybrid)

		RBP4	LAMTOR5
Description		retinol binding protein 4	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Protein-containing Complex Extracellular Exosome	Lysosome Lysosomal Membrane Cytosol Protein-containing Complex Ragulator Complex
	Molecular Function	Protein Binding Retinal Binding Retinol Binding Retinol Transmembrane Transporter Activity Protein-containing Complex Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Molecular Adaptor Activity
	Biological Process	Retinoid Metabolic Process Eye Development Positive Regulation Of Immunoglobulin Production Gluconeogenesis Heart Development Visual Perception Maintenance Of Gastrointestinal Epithelium Lung Development Positive Regulation Of Insulin Secretion Response To Retinoic Acid Retinol Transport Retinol Metabolic Process Glucose Homeostasis Response To Ethanol Embryonic Organ Morphogenesis Embryonic Skeletal System Development Cardiac Muscle Tissue Development Female Genitalia Morphogenesis Negative Regulation Of Cardiac Muscle Cell Proliferation Embryonic Retina Morphogenesis In Camera-type Eye Uterus Development Vagina Development Urinary Bladder Development Heart Trabecula Formation	Cell Cycle Arrest Regulation Of Cell Size Response To Virus Positive Regulation Of Gene Expression Regulation Of Macroautophagy Viral Genome Replication Positive Regulation Of TOR Signaling Positive Regulation Of Interleukin-8 Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of TORC1 Signaling Positive Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Pathways		Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) Retinoid metabolism disease events Retinoid metabolism and transport	Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs		Tretinoin
Diseases
GWAS		Blood protein levels ( 30072576) Optic disc area ( 31798171) Retinol levels ( 21878437)
Interacting Genes		6 interacting genes: ALB GRB2 LAMTOR5 RBBP6 RPE65 TTR	64 interacting genes: ACAA2 AKR1C2 ALB ANKRD46 ASGR1 BHMT C9 CD74 CEP126 CEP70 CFB CLIC5 DBI DNAJA3 ECT2 EEF1A1 EIF3A EIF4B GAPDH GIT1 GIT2 GPRASP1 HEBP2 HSPA9 ITGB1 KEAP1 KIF1B KMT2E LAMTOR4 LRIF1 MAF1 MCPH1 MED12L MEOX2 MKLN1 MT2A MYF6 MYH3 MYOG NCOA6 PDK1 PEG10 PPARA RABIF RBP4 SERPINA1 SFPQ SHB SKP1 SMAD4 SNX5 TAF9 TBC1D4 TCAP TCF12 TGFB1 TOP2B TP53 TRIM55 TRIM63 UTP14A YTHDC1 ZBTB16 ZNF592
Entrez ID		5950	10542
HPRD ID		01580	09773
Ensembl ID		ENSG00000138207	ENSG00000134248
Uniprot IDs		P02753 Q5VY30	A0A0C4DGV4 O43504
PDB IDs		1BRP 1BRQ 1JYD 1JYJ 1QAB 1RBP 1RLB 2WQ9 2WQA 2WR6 3BSZ 3FMZ 4O9S 4PSQ 5NTY 5NU2 5NU6 5NU7 5NU8 5NU9 5NUA 5NUB 6QBA	3MS6 3MSH 5VOK 5X6U 5X6V 5Y38 5Y39 5Y3A 5YK3 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3
Enriched GO Terms of Interacting Partners?
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