RBP4 and RBBP6

Data Source:
BioGRID (two hybrid)

		RBP4	RBBP6
Description		retinol binding protein 4	RB binding protein 6, ubiquitin ligase
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Protein-containing Complex Extracellular Exosome	Chromosome Nucleolus Centrosome Cytosol Nuclear Speck Protein-containing Complex
	Molecular Function	Protein Binding Retinal Binding Retinol Binding Retinol Transmembrane Transporter Activity Protein-containing Complex Binding	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Retinoid Metabolic Process Eye Development Positive Regulation Of Immunoglobulin Production Gluconeogenesis Heart Development Visual Perception Maintenance Of Gastrointestinal Epithelium Lung Development Positive Regulation Of Insulin Secretion Response To Retinoic Acid Retinol Transport Retinol Metabolic Process Glucose Homeostasis Response To Ethanol Embryonic Organ Morphogenesis Embryonic Skeletal System Development Cardiac Muscle Tissue Development Female Genitalia Morphogenesis Negative Regulation Of Cardiac Muscle Cell Proliferation Embryonic Retina Morphogenesis In Camera-type Eye Uterus Development Vagina Development Urinary Bladder Development Heart Trabecula Formation	Protein Polyubiquitination In Utero Embryonic Development DNA Replication Regulation Of DNA Replication MRNA Processing Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Multicellular Organism Growth Embryonic Organ Development Somite Development
Pathways		Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) Retinoid metabolism disease events Retinoid metabolism and transport	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Tretinoin
Diseases
GWAS		Blood protein levels ( 30072576) Optic disc area ( 31798171) Retinol levels ( 21878437)	Adult body size ( 32376654) Body mass index ( 28892062) Body size at age 10 ( 32376654) Brain structure ( 20171287) Chronotype ( 30696823) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		6 interacting genes: ALB GRB2 LAMTOR5 RBBP6 RPE65 TTR	40 interacting genes: ACOT13 ANAPC16 APOH ASGR1 CAPZA2 CASK CD81 CLK1 ETS1 EVA1C FAAP24 FBXO7 GLUL GRB2 HP KHDRBS3 LINC00305 LRCH4 MAD2L2 MDM2 MIR19A MIR19B1 NDUFB9 NEK6 PIAS1 PLG RB1 RBP4 RCC1L RPS14 SMN1 SPP1 TP53 TPT1 UBE2I UPF3B VAV2 YBX1 ZBTB38 ZFYVE9
Entrez ID		5950	5930
HPRD ID		01580	02964
Ensembl ID		ENSG00000138207	ENSG00000122257
Uniprot IDs		P02753 Q5VY30	Q7Z6E9
PDB IDs		1BRP 1BRQ 1JYD 1JYJ 1QAB 1RBP 1RLB 2WQ9 2WQA 2WR6 3BSZ 3FMZ 4O9S 4PSQ 5NTY 5NU2 5NU6 5NU7 5NU8 5NU9 5NUA 5NUB 6QBA	2C7H 2YSA 2YUR 3ZTG 6E5X
Enriched GO Terms of Interacting Partners?
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