RBP4 and RPE65

Data Source:
HPRD (in vitro)

		RBP4	RPE65
Description		retinol binding protein 4	retinoid isomerohydrolase RPE65
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Protein-containing Complex Extracellular Exosome	Nucleus Endoplasmic Reticulum Membrane Plasma Membrane Membrane Cell Body
	Molecular Function	Protein Binding Retinal Binding Retinol Binding Retinol Transmembrane Transporter Activity Protein-containing Complex Binding	Phosphatidylserine Binding Retinal Isomerase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Isomerase Activity Phosphatidylcholine Binding Metal Ion Binding Retinol Isomerase Activity All-trans-retinyl-palmitate Hydrolase, 11-cis Retinol Forming Activity All-trans-retinyl-ester Hydrolase, 11-cis Retinol Forming Activity Cardiolipin Binding
	Biological Process	Retinoid Metabolic Process Eye Development Positive Regulation Of Immunoglobulin Production Gluconeogenesis Heart Development Visual Perception Maintenance Of Gastrointestinal Epithelium Lung Development Positive Regulation Of Insulin Secretion Response To Retinoic Acid Retinol Transport Retinol Metabolic Process Glucose Homeostasis Response To Ethanol Embryonic Organ Morphogenesis Embryonic Skeletal System Development Cardiac Muscle Tissue Development Female Genitalia Morphogenesis Negative Regulation Of Cardiac Muscle Cell Proliferation Embryonic Retina Morphogenesis In Camera-type Eye Uterus Development Vagina Development Urinary Bladder Development Heart Trabecula Formation	Retinoid Metabolic Process Retina Homeostasis Neural Retina Development Vitamin A Metabolic Process Visual Perception Circadian Rhythm Insulin Receptor Signaling Pathway Regulation Of Gene Expression Retinol Metabolic Process Retinal Metabolic Process Detection Of Light Stimulus Involved In Visual Perception Retina Morphogenesis In Camera-type Eye Cellular Response To Electrical Stimulus Zeaxanthin Biosynthetic Process
Pathways		Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) Retinoid metabolism disease events Retinoid metabolism and transport	The canonical retinoid cycle in rods (twilight vision)
Drugs		Tretinoin	Voretigene neparvovec
Diseases			Leber congenital amaurosis (LCR) Retinitis pigmentosa (RP)
GWAS		Blood protein levels ( 30072576) Optic disc area ( 31798171) Retinol levels ( 21878437)	Facial morphology ( 31763980) Mortality in sepsis ( 27639821) Vertical cup-disc ratio ( 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		6 interacting genes: ALB GRB2 LAMTOR5 RBBP6 RPE65 TTR	2 interacting genes: RBP4 SLC27A1
Entrez ID		5950	6121
HPRD ID		01580	01569
Ensembl ID		ENSG00000138207	ENSG00000116745
Uniprot IDs		P02753 Q5VY30	Q16518
PDB IDs		1BRP 1BRQ 1JYD 1JYJ 1QAB 1RBP 1RLB 2WQ9 2WQA 2WR6 3BSZ 3FMZ 4O9S 4PSQ 5NTY 5NU2 5NU6 5NU7 5NU8 5NU9 5NUA 5NUB 6QBA
Enriched GO Terms of Interacting Partners?
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