RIT1 and KLHL12

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		RIT1	KLHL12
Description		Ras like without CAAX 1	kelch like family member 12
Image
GO Annotations	Cellular Component	Plasma Membrane	Golgi Membrane Cytosol COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite Intracellular Membrane-bounded Organelle
	Molecular Function	GTPase Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding	Protein Binding Identical Protein Binding
	Biological Process	Signal Transduction Ras Protein Signal Transduction	Protein Monoubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Neural Crest Formation Neural Crest Cell Development Wnt Signaling Pathway COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Signalling to p38 via RIT and RIN	Degradation of DVL
Drugs
Diseases
GWAS		Birth weight ( 31043758) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908 23128233) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		17 interacting genes: AFDN AP2A1 CUL3 IFRD1 KLHL12 LRIF1 LRRK2 LZTR1 PTN RALGDS RGL1 RGL3 RLF SMAD2 SMAD3 SMURF1 SRPK2	62 interacting genes: ARAF ARRDC1 ATXN1 BAG6 BCL6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CRTC3 CUL3 DGCR6 DRD4 DVL1 DVL2 DVL3 FAM90A1 FBXL17 FGD2 FLNA GLYCTK INMT KHSRP KLHL2 KLHL24 KLHL3 LNPK LNX1 MAPRE1 MED25 MED28 MPP1 MRPL10 MTNR1A MYO15B NDC80 NTAQ1 PDGFRB PEA15 PEF1 PLEKHA4 PNKP PRR13 RGL3 RIN1 RIT1 RNF4 RPP25L SDCBP SEC31A SNX20 SYNE4 TAOK2 TBC1D10C TCEANC TTBK2 UBE2I VEGFB VTA1 ZBP1 ZBTB4
Entrez ID		6016	59349
HPRD ID		10195	13925
Ensembl ID		ENSG00000143622	ENSG00000117153
Uniprot IDs		Q92963	Q53G59 Q9H7R2
PDB IDs		4KLZ	2VPJ 6TTK 6V7O
Enriched GO Terms of Interacting Partners?
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