LAMTOR5 and TOP2B

Data Source:
BioGRID (two hybrid)

		LAMTOR5	TOP2B
Description		late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	DNA topoisomerase II beta
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Cytosol Protein-containing Complex Ragulator Complex	Heterochromatin Nucleus Nucleoplasm Nucleolus Cytosol Ribonucleoprotein Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Molecular Adaptor Activity	DNA Binding Chromatin Binding DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Activity Protein Kinase C Binding ATP Binding Protein C-terminus Binding Enzyme Binding Histone Deacetylase Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Cell Cycle Arrest Regulation Of Cell Size Response To Virus Positive Regulation Of Gene Expression Regulation Of Macroautophagy Viral Genome Replication Positive Regulation Of TOR Signaling Positive Regulation Of Interleukin-8 Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of TORC1 Signaling Positive Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding	Resolution Of Meiotic Recombination Intermediates Sister Chromatid Segregation Neuron Migration DNA Topological Change Axonogenesis Forebrain Development Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	SUMOylation of DNA replication proteins
Drugs			Dexrazoxane Daunorubicin Etoposide Dactinomycin Phosphoaminophosphonic Acid-Adenylate Ester Amonafide Technetium Tc-99m ciprofloxacin ZEN-012 Becatecarin Declopramide 3'-THIO-THYMIDINE-5'-PHOSPHATE
Diseases
GWAS			Chronic obstructive pulmonary disease ( 30804561)
Interacting Genes		64 interacting genes: ACAA2 AKR1C2 ALB ANKRD46 ASGR1 BHMT C9 CD74 CEP126 CEP70 CFB CLIC5 DBI DNAJA3 ECT2 EEF1A1 EIF3A EIF4B GAPDH GIT1 GIT2 GPRASP1 HEBP2 HSPA9 ITGB1 KEAP1 KIF1B KMT2E LAMTOR4 LRIF1 MAF1 MCPH1 MED12L MEOX2 MKLN1 MT2A MYF6 MYH3 MYOG NCOA6 PDK1 PEG10 PPARA RABIF RBP4 SERPINA1 SFPQ SHB SKP1 SMAD4 SNX5 TAF9 TBC1D4 TCAP TCF12 TGFB1 TOP2B TP53 TRIM55 TRIM63 UTP14A YTHDC1 ZBTB16 ZNF592	17 interacting genes: CD3E CSNK2B ERG HDAC1 HDAC2 LAMTOR5 MAPK3 RANBP2 RARA SUMO1 SUMO2 TOP2A TOPBP1 TP53 UBE2I XPO1 XRCC5
Entrez ID		10542	7155
HPRD ID		09773	00537
Ensembl ID		ENSG00000134248	ENSG00000077097
Uniprot IDs		A0A0C4DGV4 O43504	Q02880 Q59H80
PDB IDs		3MS6 3MSH 5VOK 5X6U 5X6V 5Y38 5Y39 5Y3A 5YK3 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3	3QX3 4G0U 4G0V 4G0W 4J3N 5GWI 5GWJ 5ZAD 5ZEN 5ZQF 5ZRF
Enriched GO Terms of Interacting Partners?
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