KMT2C and APPL2

Data Source:
BioGRID (two hybrid)

		KMT2C	APPL2
Description		lysine methyltransferase 2C	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex	Ruffle Nucleus Endosome Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Vesicle Early Phagosome Ruffle Membrane Early Phagosome Membrane Macropinosome Extracellular Exosome
	Molecular Function	DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transferase Activity, Transferring Acyl Groups Histone Methyltransferase Activity Histone Binding Histone Methyltransferase Activity (H3-K4 Specific) Metal Ion Binding	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding
	Biological Process	Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Histone H3-K4 Monomethylation	Diet Induced Thermogenesis Protein Import Into Nucleus Cell Cycle Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cold Acclimation Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Glucose Homeostasis Regulation Of Innate Immune Response Negative Regulation Of Fatty Acid Oxidation Negative Regulation Of Glucose Import Negative Regulation Of Neurogenesis Protein Homotetramerization Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Macropinocytosis Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS			Mosquito bite size ( 28199695)
Interacting Genes		11 interacting genes: APPL2 DPY30 H3-4 H3C1 H3C14 H4C1 JUN MAPK14 MTNR1B SMARCB1 TSC22D1	29 interacting genes: APPL1 ATF3 CNMD CRADD CRBN CRLF3 DOK3 EPM2AIP1 KIFC3 KMT2C LDHAL6B LGALS9C LINC02875 LIX1 MLST8 MTA2 PINK1 POT1 PRR35 RAB22A RAB5A RAB5C RAI2 RBBP7 RBP7 RUVBL2 SUV39H2 TINF2 TSC1
Entrez ID		58508	55198
HPRD ID		06016	06945
Ensembl ID		ENSG00000055609	ENSG00000136044
Uniprot IDs		Q8NEZ4	Q8NEU8
PDB IDs		2YSM 2YUK 3UVL 4ERY 5F59 5F6K 6KIW 6MLC	4H8S 5C5B
Enriched GO Terms of Interacting Partners?
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