KMT2C and TSC22D1

Data Source:
BioGRID (two hybrid)

		KMT2C	TSC22D1
Description		lysine methyltransferase 2C	TSC22 domain family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex	Nucleus Cytoplasm
	Molecular Function	DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transferase Activity, Transferring Acyl Groups Histone Methyltransferase Activity Histone Binding Histone Methyltransferase Activity (H3-K4 Specific) Metal Ion Binding	Protein Binding
	Biological Process	Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Histone H3-K4 Monomethylation	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II
Pathways		PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS			Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Body mass index ( 25760438) Refractive error ( 32231278) Rosacea symptom severity ( 29771307)
Interacting Genes		11 interacting genes: APPL2 DPY30 H3-4 H3C1 H3C14 H4C1 JUN MAPK14 MTNR1B SMARCB1 TSC22D1	50 interacting genes: A2M APLP1 ASAH1 CACNA1A CARHSP1 CCDC90B CHD3 CORO2B CRMP1 DDAH2 DNMT3B EED ERG28 FAF1 FAM20C FBN3 GNB2 GNB5 GORASP2 HMGXB4 KMT2B KMT2C LRIF1 MAP3K12 MCM3AP NCOA5 NTAQ1 OTUB1 PDHB PRKCI PTN QARS1 RGS1 RPL5 SETDB1 SP110 SPACA9 SPRED1 TAF5L TGFBR1 TLE1 TP53 TSC22D4 UBE2D1 UNC119 VIM WDR73 WIZ WNK1 ZC3HC1
Entrez ID		58508	8848
HPRD ID		06016	07414
Ensembl ID		ENSG00000055609	ENSG00000102804
Uniprot IDs		Q8NEZ4	A0A024RDV8 A0A087X0H8 A8K3Y6 Q15714
PDB IDs		2YSM 2YUK 3UVL 4ERY 5F59 5F6K 6KIW 6MLC
Enriched GO Terms of Interacting Partners?
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