APPL2 and MLST8

Data Source:
BioGRID (two hybrid)

		APPL2	MLST8
Description		adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2	MTOR associated protein, LST8 homolog
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GO Annotations	Cellular Component	Ruffle Nucleus Endosome Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Vesicle Early Phagosome Ruffle Membrane Early Phagosome Membrane Macropinosome Extracellular Exosome	Nucleoplasm Cytoplasm Cytosol TORC1 Complex TORC2 Complex
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding	Protein Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Diet Induced Thermogenesis Protein Import Into Nucleus Cell Cycle Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cold Acclimation Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Glucose Homeostasis Regulation Of Innate Immune Response Negative Regulation Of Fatty Acid Oxidation Negative Regulation Of Glucose Import Negative Regulation Of Neurogenesis Protein Homotetramerization Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Macropinocytosis Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Neural Precursor Cell Proliferation	Cell Cycle Arrest Regulation Of Macroautophagy TOR Signaling Positive Regulation Of TOR Signaling Activation Of Protein Kinase B Activity Regulation Of Actin Cytoskeleton Organization TORC1 Signaling Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cellular Response To Heat
Pathways			PIP3 activates AKT signaling Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Mosquito bite size ( 28199695)	Height ( 28552196)
Interacting Genes		29 interacting genes: APPL1 ATF3 CNMD CRADD CRBN CRLF3 DOK3 EPM2AIP1 KIFC3 KMT2C LDHAL6B LGALS9C LINC02875 LIX1 MLST8 MTA2 PINK1 POT1 PRR35 RAB22A RAB5A RAB5C RAI2 RBBP7 RBP7 RUVBL2 SUV39H2 TINF2 TSC1	7 interacting genes: A2M APPL2 ATXN1 EIF4EBP1 MTOR PRMT1 RPTOR
Entrez ID		55198	64223
HPRD ID		06945	17031
Ensembl ID		ENSG00000136044	ENSG00000167965
Uniprot IDs		Q8NEU8	Q9BVC4
PDB IDs		4H8S 5C5B	4JSN 4JSP 4JSV 4JSX 4JT5 4JT6 5FLC 5H64 5WBU 5WBY 5ZCS 6BCU 6BCX 6SB0 6SB2
Enriched GO Terms of Interacting Partners?
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