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RAD1 and SIRT6
Data Source:
BioGRID
(pull down)
RAD1
SIRT6
Description
RAD1 checkpoint DNA exonuclease
sirtuin 6
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Chromosome
Checkpoint Clamp Complex
Intracellular Membrane-bounded Organelle
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Chromosome, Subtelomeric Region
Molecular Function
Damaged DNA Binding
Protein Binding
3'-5' Exonuclease Activity
Exodeoxyribonuclease III Activity
Transcription Corepressor Activity
NAD+ ADP-ribosyltransferase Activity
NAD(P)+-protein-arginine ADP-ribosyltransferase Activity
Histone Deacetylase Activity
Protein Binding
Zinc Ion Binding
NAD-dependent Histone Deacetylase Activity
Deacetylase Activity
NAD-dependent Protein Deacetylase Activity
NAD-dependent Histone Deacetylase Activity (H3-K9 Specific)
NAD+ Binding
Biological Process
DNA Damage Checkpoint
DNA Replication
DNA Repair
Cellular Response To DNA Damage Stimulus
Substantia Nigra Development
Meiotic Recombination Checkpoint
Cellular Response To Ionizing Radiation
Nucleic Acid Phosphodiester Bond Hydrolysis
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Transcription By RNA Polymerase II
Post-embryonic Cardiac Muscle Cell Growth Involved In Heart Morphogenesis
Protein ADP-ribosylation
Protein Deacetylation
Regulation Of Double-strand Break Repair Via Homologous Recombination
Response To Nutrient Levels
Positive Regulation Of Chromatin Silencing At Telomere
Positive Regulation Of Telomere Maintenance
Histone H3-K9 Modification
Histone H3 Deacetylation
Positive Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Transcription Factor Catabolic Process
Positive Regulation Of Chondrocyte Proliferation
Positive Regulation Of Subtelomeric Heterochromatin Assembly
Positive Regulation Of Blood Vessel Branching
Positive Regulation Of Vascular Endothelial Cell Proliferation
Histone H3-K9 Deacetylation
Pathways
Activation of ATR in response to replication stress
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Pre-NOTCH Transcription and Translation
Processing of DNA double-strand break ends
Drugs
Diseases
GWAS
Daytime sleep phenotypes (
27126917
)
Interacting Genes
24 interacting genes:
COPS5
CSNK2A1
CSNK2A2
DNAJC7
FEN1
HUS1
HUS1B
MAP1LC3B
MSH2
MSH3
MSH6
NEIL1
OGG1
POLB
PRKN
RAD17
RAD9B
RHNO1
RPA1
RPA2
SIRT6
TDG
TOPBP1
WRN
17 interacting genes:
AKT1
CCNDBP1
CDKN1B
CHD3
ELF5
FAF1
HUS1
MUTYH
RAD1
SKP2
STUB1
TDG
TSPYL2
UBE2D1
UBE3A
USP10
VIM
Entrez ID
5810
51548
HPRD ID
04400
12093
Ensembl ID
ENSG00000113456
ENSG00000077463
Uniprot IDs
A0A024R045
O60671
B4DDV3
M0QXA0
M0R1N9
Q8N6T7
PDB IDs
3A1J
3G65
3GGR
6J8Y
3K35
3PKI
3PKJ
3ZG6
5MF6
5MFP
5MFZ
5MGN
5X16
5Y2F
6HOY
6QCD
6QCE
6QCH
6QCJ
6XUY
6XV1
6XV6
6XVG
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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