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SIRT6 and MUTYH
Data Source:
BioGRID
(affinity chromatography technology, pull down)
SIRT6
MUTYH
Description
sirtuin 6
mutY DNA glycosylase
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Chromosome, Subtelomeric Region
Nucleus
Nucleoplasm
Mitochondrion
Molecular Function
Transcription Corepressor Activity
NAD+ ADP-ribosyltransferase Activity
NAD(P)+-protein-arginine ADP-ribosyltransferase Activity
Histone Deacetylase Activity
Protein Binding
Zinc Ion Binding
NAD-dependent Histone Deacetylase Activity
Deacetylase Activity
NAD-dependent Protein Deacetylase Activity
NAD-dependent Histone Deacetylase Activity (H3-K9 Specific)
NAD+ Binding
Purine-specific Mismatch Base Pair DNA N-glycosylase Activity
Protein Binding
DNA N-glycosylase Activity
Oxidized Purine DNA Binding
MutLalpha Complex Binding
MutLbeta Complex Binding
MutSalpha Complex Binding
MutSbeta Complex Binding
8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity
Adenine/guanine Mispair Binding
Metal Ion Binding
4 Iron, 4 Sulfur Cluster Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Post-embryonic Cardiac Muscle Cell Growth Involved In Heart Morphogenesis
Protein ADP-ribosylation
Protein Deacetylation
Regulation Of Double-strand Break Repair Via Homologous Recombination
Response To Nutrient Levels
Positive Regulation Of Chromatin Silencing At Telomere
Positive Regulation Of Telomere Maintenance
Histone H3-K9 Modification
Histone H3 Deacetylation
Positive Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Transcription Factor Catabolic Process
Positive Regulation Of Chondrocyte Proliferation
Positive Regulation Of Subtelomeric Heterochromatin Assembly
Positive Regulation Of Blood Vessel Branching
Positive Regulation Of Vascular Endothelial Cell Proliferation
Histone H3-K9 Deacetylation
DNA Repair
Base-excision Repair
Mismatch Repair
Depurination
Pathways
Pre-NOTCH Transcription and Translation
Processing of DNA double-strand break ends
Drugs
Diseases
Familial adenomatous polyposis
GWAS
Composite immunoglobulin trait (IgA/IgM) (
28628107
)
Periventricular white matter hyperintensities (
32517579
)
Interacting Genes
17 interacting genes:
AKT1
CCNDBP1
CDKN1B
CHD3
ELF5
FAF1
HUS1
MUTYH
RAD1
SKP2
STUB1
TDG
TSPYL2
UBE2D1
UBE3A
USP10
VIM
19 interacting genes:
AGTRAP
APEX1
BAAT
CYLC2
FANCC
HRAS
LMNA
LRSAM1
MSANTD3
MSH6
PCNA
RPA1
RPA4
SEC61B
SIRT6
SMAD1
TDRD7
TSTD2
XPA
Entrez ID
51548
4595
HPRD ID
12093
05380
Ensembl ID
ENSG00000077463
ENSG00000132781
Uniprot IDs
B4DDV3
M0QXA0
M0R1N9
Q8N6T7
D3DPZ6
E5KP25
E5KP26
E5KP27
E5KP28
E9PM53
Q9UIF7
PDB IDs
3K35
3PKI
3PKJ
3ZG6
5MF6
5MFP
5MFZ
5MGN
5X16
5Y2F
6HOY
6QCD
6QCE
6QCH
6QCJ
6XUY
6XV1
6XV6
6XVG
1X51
3N5N
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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