THAP11 and TPX2

Data Source:
BioGRID (two hybrid)

		THAP11	TPX2
Description		THAP domain containing 11	TPX2 microtubule nucleation factor
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GO Annotations	Cellular Component	Chromatin Nucleoplasm Cytosol	Spindle Pole Nucleus Nucleoplasm Spindle Cytosol Nuclear Microtubule Microtubule Cytoskeleton Axon Hillock Intercellular Bridge Mitotic Spindle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding	Protein Binding Microtubule Binding Protein Kinase Binding Protein Kinase Activator Activity Importin-alpha Family Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II	Mitotic Cell Cycle Apoptotic Process Microtubule Nucleation Negative Regulation Of Microtubule Depolymerization Regulation Of G2/M Transition Of Mitotic Cell Cycle Activation Of Protein Kinase Activity Cell Division Regulation Of Mitotic Spindle Organization Mitotic Spindle Assembly Regulation Of Signal Transduction By P53 Class Mediator
Pathways			Regulation of TP53 Activity through Phosphorylation AURKA Activation by TPX2
Drugs
Diseases
GWAS		Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252) Schizophrenia ( 25056061 29483656)	Brain morphology (MOSTest) ( 32665545) Immature fraction of reticulocytes ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Prudent dietary pattern ( 28644415)
Interacting Genes		20 interacting genes: BBLN CASP3 CTBP1 ECT2 HCFC1 HDAC1 HDAC3 HEMGN L3MBTL2 LRRC45 MCPH1 NUTF2 PFDN6 PSMC5 SIN3A SLX1B SRSF11 THAP7 TPX2 VPS52	8 interacting genes: AURKA CDK6 GOLGA2 HMMR NAP1L1 SIAH2 SUMO2 THAP11
Entrez ID		57215	22974
HPRD ID		11629	05802
Ensembl ID		ENSG00000168286	ENSG00000088325
Uniprot IDs		Q96EK4	Q643R0 Q9ULW0
PDB IDs		2LAU 5AJS	1OL5 3E5A 3HA6 4C3P 5LXM 6BJC 6VPG 6VPH 6VPI 6VPJ 6VPL 6VPM 6XKA
Enriched GO Terms of Interacting Partners?
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