TPX2 and HMMR

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		TPX2	HMMR
Description		TPX2 microtubule nucleation factor	hyaluronan mediated motility receptor
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Spindle Cytosol Nuclear Microtubule Microtubule Cytoskeleton Axon Hillock Intercellular Bridge Mitotic Spindle	Centrosome Cytosol Plasma Membrane Cell Surface Microtubule Cytoskeleton Membrane
	Molecular Function	Protein Binding Microtubule Binding Protein Kinase Binding Protein Kinase Activator Activity Importin-alpha Family Protein Binding	Protein Binding Hyaluronic Acid Binding
	Biological Process	Mitotic Cell Cycle Apoptotic Process Microtubule Nucleation Negative Regulation Of Microtubule Depolymerization Regulation Of G2/M Transition Of Mitotic Cell Cycle Activation Of Protein Kinase Activity Cell Division Regulation Of Mitotic Spindle Organization Mitotic Spindle Assembly Regulation Of Signal Transduction By P53 Class Mediator	Regulation Of G2/M Transition Of Mitotic Cell Cycle Hyaluronan Catabolic Process
Pathways		Regulation of TP53 Activity through Phosphorylation AURKA Activation by TPX2	Hyaluronan uptake and degradation AURKA Activation by TPX2
Drugs			Hyaluronic acid
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Immature fraction of reticulocytes ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Prudent dietary pattern ( 28644415)	Metabolite levels ( 23823483)
Interacting Genes		8 interacting genes: AURKA CDK6 GOLGA2 HMMR NAP1L1 SIAH2 SUMO2 THAP11	16 interacting genes: ACTB BACH1 CALM1 CD44 CDH13 GREB1 IL24 ITIH5 MAPK3 MORN4 NAT2 SVIL THRSP TPX2 TRIM54 TUBB2A
Entrez ID		22974	3161
HPRD ID		05802	02963
Ensembl ID		ENSG00000088325	ENSG00000072571
Uniprot IDs		Q643R0 Q9ULW0	O75330
PDB IDs		1OL5 3E5A 3HA6 4C3P 5LXM 6BJC 6VPG 6VPH 6VPI 6VPJ 6VPL 6VPM 6XKA
Enriched GO Terms of Interacting Partners?
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Tagcloud (Intersection) ?