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SMCO4 and SCN3B
Data Source:
BioGRID
(two hybrid)
SMCO4
SCN3B
Description
single-pass membrane protein with coiled-coil domains 4
sodium voltage-gated channel beta subunit 3
Image
No pdb structure
GO Annotations
Cellular Component
Cellular_component
Integral Component Of Membrane
Voltage-gated Sodium Channel Complex
Plasma Membrane
Integral Component Of Membrane
Z Disc
Molecular Function
Molecular_function
Protein Binding
Voltage-gated Ion Channel Activity
Protein Binding
Sodium Channel Regulator Activity
Sodium Channel Inhibitor Activity
Ion Channel Binding
Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential
Biological Process
Biological_process
Sodium Ion Transport
Nervous System Development
Positive Regulation Of Heart Rate
Positive Regulation Of Sodium Ion Transport
Sensory Perception Of Pain
Sodium Ion Transmembrane Transport
Membrane Depolarization
Cardiac Muscle Contraction
Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization
Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization
Protein Localization To Plasma Membrane
Cardiac Muscle Cell Action Potential Involved In Contraction
Ventricular Cardiac Muscle Cell Action Potential
Membrane Depolarization During Action Potential
Membrane Depolarization During Cardiac Muscle Cell Action Potential
Atrial Cardiac Muscle Cell Action Potential
SA Node Cell Action Potential
Regulation Of Heart Rate By Cardiac Conduction
Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways
Interaction between L1 and Ankyrins
Phase 0 - rapid depolarisation
Drugs
Ranolazine
Valproic acid
Oxcarbazepine
Cocaine
Zonisamide
Brivaracetam
Dichlorobenzyl alcohol
Fish oil
Diseases
Brugada syndrome (BRS)
GWAS
Adult body size (
32376654
)
Insulin levels in response to oral glucose tolerance test (30 minutes) (
29093273
)
Chronic lymphocytic leukemia (
28165464
24292274
23770605
)
Response to citalopram or escitalopram in depression (
27622933
)
Interacting Genes
59 interacting genes:
AQP6
BNIP3L
CD79A
CLEC10A
CLTRN
CPLX4
CREB3L1
CXCR2
EBP
ERGIC3
FAM174A
FAM209A
FAM210B
FFAR2
GJA8
GKN1
GPA33
GPR152
GPR42
HHLA2
ICAM3
IL10RA
KASH5
KCNK5
KIR3DL1
KRT40
KRTAP10-3
KRTAP10-7
LEPROTL1
LMNA
LRRC25
M6PR
MGST3
MS4A3
MUC1
PEX12
PLD3
PTGES
RETREG3
SCN3B
SLC16A2
SLC18A1
SLC35C2
SLC41A3
SLC7A1
SLC7A14
SMIM3
SPINT1
STOM
SUSD3
SYNE4
SYNPR
TEX29
TFEC
TMEM139
TMEM80
TMX2
VSIR
WBP1
105 interacting genes:
ADIPOQ
AGPAT4
AGPAT5
ANKRD46
AQP10
ARV1
ATP13A1
ATP6V0C
BNIP1
BNIP3
BRICD5
CLCA4
CTXN3
CYP4F2
DEFB103A
DEFB103B
DERL1
DGAT2L6
ERG28
FAM241B
FAM3C
FIS1
FKBP8
FXYD3
GIMAP1
GIMAP5
GPR151
GPR61
IER3IP1
INSIG2
ISM2
ITGAM
LEMD1
LEPROTL1
LPAR3
MAL2
MARCHF2
MFSD5
MGST3
MS4A13
NFASC
NINJ2
ORMDL1
ORMDL2
PLBD2
PLP2
PLPPR2
PMP22
RHD
RNF8
RUSF1
SACM1L
SCD
SEC22A
SERP2
SFT2D1
SFXN1
SFXN3
SLC2A5
SLC30A3
SLC30A8
SLC35A4
SLC35E4
SLC38A1
SLC38A7
SLC7A1
SMCO4
SMIM1
STRIT1
STX3
STX6
STX8
THSD7A
TIMM23
TM6SF2
TMBIM6
TMEM120A
TMEM120B
TMEM128
TMEM140
TMEM14A
TMEM14B
TMEM208
TMEM239
TMEM243
TMEM42
TMEM50B
TMEM60
TMEM65
TMEM86A
TMPPE
TPRG1
TRARG1
TSPAN2
TVP23B
UBIAD1
USE1
VAMP1
VAMP2
VAMP3
VAPA
VAPB
YIF1A
YIPF4
ZFPL1
Entrez ID
56935
55800
HPRD ID
17008
10497
Ensembl ID
ENSG00000166002
ENSG00000166257
Uniprot IDs
A0A024R3A3
Q9NRQ5
A0A024R3H7
Q9NY72
PDB IDs
4L1D
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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