SCN3B and SLC38A7

Data Source:
BioGRID (two hybrid)

		SCN3B	SLC38A7
Description		sodium voltage-gated channel beta subunit 3	solute carrier family 38 member 7
Image			No pdb structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Membrane Z Disc	Integral Component Of Membrane Axon Neuronal Cell Body
	Molecular Function	Voltage-gated Ion Channel Activity Protein Binding Sodium Channel Regulator Activity Sodium Channel Inhibitor Activity Ion Channel Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential	L-histidine Transmembrane Transporter Activity L-glutamate Transmembrane Transporter Activity Protein Binding Amino Acid Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity L-asparagine Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity L-glutamine Transmembrane Transporter Activity L-leucine Transmembrane Transporter Activity L-methionine Transmembrane Transporter Activity L-serine Transmembrane Transporter Activity
	Biological Process	Sodium Ion Transport Nervous System Development Positive Regulation Of Heart Rate Positive Regulation Of Sodium Ion Transport Sensory Perception Of Pain Sodium Ion Transmembrane Transport Membrane Depolarization Cardiac Muscle Contraction Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity	Amino Acid Transmembrane Transport Sodium Ion Transport Asparagine Transport Glutamine Transport Branched-chain Amino Acid Transport L-alanine Transport L-glutamate Transmembrane Transport Methionine Transport L-serine Transport L-aspartate Transmembrane Transport L-histidine Transmembrane Transport
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs		Ranolazine Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil
Diseases		Brugada syndrome (BRS)
GWAS		Chronic lymphocytic leukemia ( 28165464 24292274 23770605) Response to citalopram or escitalopram in depression ( 27622933)	Plasma anastrozole concentration in anastrozole-treated estrogen receptor positive breast cancer ( 30648747) QT interval ( 19305408) Schizophrenia ( 25056061 29483656)
Interacting Genes		105 interacting genes: ADIPOQ AGPAT4 AGPAT5 ANKRD46 AQP10 ARV1 ATP13A1 ATP6V0C BNIP1 BNIP3 BRICD5 CLCA4 CTXN3 CYP4F2 DEFB103A DEFB103B DERL1 DGAT2L6 ERG28 FAM241B FAM3C FIS1 FKBP8 FXYD3 GIMAP1 GIMAP5 GPR151 GPR61 IER3IP1 INSIG2 ISM2 ITGAM LEMD1 LEPROTL1 LPAR3 MAL2 MARCHF2 MFSD5 MGST3 MS4A13 NFASC NINJ2 ORMDL1 ORMDL2 PLBD2 PLP2 PLPPR2 PMP22 RHD RNF8 RUSF1 SACM1L SCD SEC22A SERP2 SFT2D1 SFXN1 SFXN3 SLC2A5 SLC30A3 SLC30A8 SLC35A4 SLC35E4 SLC38A1 SLC38A7 SLC7A1 SMCO4 SMIM1 STRIT1 STX3 STX6 STX8 THSD7A TIMM23 TM6SF2 TMBIM6 TMEM120A TMEM120B TMEM128 TMEM140 TMEM14A TMEM14B TMEM208 TMEM239 TMEM243 TMEM42 TMEM50B TMEM60 TMEM65 TMEM86A TMPPE TPRG1 TRARG1 TSPAN2 TVP23B UBIAD1 USE1 VAMP1 VAMP2 VAMP3 VAPA VAPB YIF1A YIPF4 ZFPL1	52 interacting genes: ACBD5 AMIGO1 APH1A AQP2 AQP9 ARL13B BTNL9 CLCN7 CLDN7 CLEC10A CPLX4 CREB3L3 CYB561 CYB5R3 EDA ERGIC3 ERP29 EVI2B FAM209A FCER1G FKBP7 GJA8 GJB5 GPR152 GPR42 IL10RA KIR2DL3 LMNA LY6G6C LYVE1 MMGT1 MUC1 ODF4 OPRM1 PANX1 PDCD1LG2 RNF5 SCN3B SERP2 SHISAL1 SLC10A1 SLC16A2 SLC18A1 SLC23A2 SLC30A2 SPINT1 SSMEM1 SYPL2 TMEM237 TMEM52B TSPAN8 YIPF6
Entrez ID		55800	55238
HPRD ID		10497	07701
Ensembl ID		ENSG00000166257	ENSG00000103042
Uniprot IDs		A0A024R3H7 Q9NY72	H3BMC5 Q9NVC3
PDB IDs		4L1D
Enriched GO Terms of Interacting Partners?
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