WRNIP1 and POLD2

Data Source:
HPRD (in vitro)

		WRNIP1	POLD2
Description		WRN helicase interacting protein 1	DNA polymerase delta 2, accessory subunit
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Membrane Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Zeta DNA Polymerase Complex DNA Polymerase Complex Delta DNA Polymerase Complex
	Molecular Function	DNA Binding Protein Binding ATP Binding Enzyme Activator Activity ATPase Activity Single-stranded DNA Helicase Activity Identical Protein Binding Metal Ion Binding	DNA Binding Protein Binding
	Biological Process	DNA Synthesis Involved In DNA Repair DNA-dependent DNA Replication Regulation Of DNA Repair Regulation Of DNA-dependent DNA Replication Initiation DNA Duplex Unwinding Innate Immune Response Regulation Of Catalytic Activity	Telomere Maintenance DNA Replication DNA Strand Elongation Involved In DNA Replication Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication Nucleotide-excision Repair, DNA Incision DNA Damage Response, Detection Of DNA Damage DNA Biosynthetic Process
Pathways			Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs
Diseases
GWAS		Plateletcrit ( 32888494)
Interacting Genes		12 interacting genes: ABL1 ERBB3 PCNA PIK3R3 PIN1 POLD1 POLD2 POLD4 TOLLIP TRIM14 UBC WRN	18 interacting genes: CCHCR1 CDK2 CDKN1A EP300 ERBB2 KCTD13 LSM6 PCNA POLD1 POLD3 POLD4 POLDIP2 POLDIP3 POLH SOX12 WRN WRNIP1 XRN1
Entrez ID		56897	5425
HPRD ID		10494	15982
Ensembl ID		ENSG00000124535	ENSG00000106628
Uniprot IDs		Q96S55	A0A087WWF6 P49005
PDB IDs		3VHS 3VHT	3E0J 6S1M 6S1N 6S1O 6TNY 6TNZ
Enriched GO Terms of Interacting Partners?
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