POLD2 and POLD4

Data Source:
BioGRID (affinity chromatography technology, pull down, pull down)

		POLD2	POLD4
Description		DNA polymerase delta 2, accessory subunit	DNA polymerase delta 4, accessory subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Zeta DNA Polymerase Complex DNA Polymerase Complex Delta DNA Polymerase Complex	Nucleoplasm Delta DNA Polymerase Complex
	Molecular Function	DNA Binding Protein Binding	DNA-directed DNA Polymerase Activity Protein Binding
	Biological Process	Telomere Maintenance DNA Replication DNA Strand Elongation Involved In DNA Replication Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication Nucleotide-excision Repair, DNA Incision DNA Damage Response, Detection Of DNA Damage DNA Biosynthetic Process	Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA-dependent DNA Replication Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication Nucleotide-excision Repair, DNA Incision DNA Damage Response, Detection Of DNA Damage
Pathways		Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand	Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs
Diseases
GWAS			Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)
Interacting Genes		18 interacting genes: CCHCR1 CDK2 CDKN1A EP300 ERBB2 KCTD13 LSM6 PCNA POLD1 POLD3 POLD4 POLDIP2 POLDIP3 POLH SOX12 WRN WRNIP1 XRN1	9 interacting genes: DTL PCNA POLD1 POLD2 POLD3 POLE RNF8 SEC23IP WRNIP1
Entrez ID		5425	57804
HPRD ID		15982	17873
Ensembl ID		ENSG00000106628	ENSG00000175482
Uniprot IDs		A0A087WWF6 P49005	A0A024R5D7 Q6NSD7 Q9HCU8
PDB IDs		3E0J 6S1M 6S1N 6S1O 6TNY 6TNZ	6HVO 6S1M 6S1N 6S1O 6TNY 6TNZ
Enriched GO Terms of Interacting Partners?
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