POLD2 and POLH

Data Source:
BioGRID (two hybrid, pull down)

		POLD2	POLH
Description		DNA polymerase delta 2, accessory subunit	DNA polymerase eta
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Zeta DNA Polymerase Complex DNA Polymerase Complex Delta DNA Polymerase Complex	Nucleus Nucleoplasm Replication Fork Cytosol Site Of Double-strand Break
	Molecular Function	DNA Binding Protein Binding	Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Metal Ion Binding
	Biological Process	Telomere Maintenance DNA Replication DNA Strand Elongation Involved In DNA Replication Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication Nucleotide-excision Repair, DNA Incision DNA Damage Response, Detection Of DNA Damage DNA Biosynthetic Process	DNA Synthesis Involved In DNA Repair DNA Replication DNA Repair Regulation Of DNA Repair Pyrimidine Dimer Repair Response To Radiation Response To UV-C Translesion Synthesis Error-prone Translesion Synthesis Error-free Translesion Synthesis Cellular Response To UV-C
Pathways		Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand	Translesion Synthesis by POLH Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR)
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS			Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		18 interacting genes: CCHCR1 CDK2 CDKN1A EP300 ERBB2 KCTD13 LSM6 PCNA POLD1 POLD3 POLD4 POLDIP2 POLDIP3 POLH SOX12 WRN WRNIP1 XRN1	9 interacting genes: APP DYNLL1 PCNA POLD2 POLI REV1 RPS27A UBC WBP2
Entrez ID		5425	5429
HPRD ID		15982	04913
Ensembl ID		ENSG00000106628	ENSG00000170734
Uniprot IDs		A0A087WWF6 P49005	A0A024RD62 B3KN75 B4DG64 Q9Y253
PDB IDs		3E0J 6S1M 6S1N 6S1O 6TNY 6TNZ	2I5O 2LSK 3JAA 3MR2 3MR3 3MR5 3MR6 3SI8 3TQ1 3WUP 4DL2 4DL3 4DL4 4DL5 4DL6 4DL7 4ECQ 4ECR 4ECS 4ECT 4ECU 4ECV 4ECW 4ECX 4ECY 4ECZ 4ED0 4ED1 4ED2 4ED3 4ED6 4ED7 4ED8 4EEY 4J9K 4J9L 4J9M 4J9N 4J9O 4J9P 4J9Q 4J9R 4J9S 4O3N 4O3O 4O3P 4O3Q 4O3R 4O3S 4Q8E 4Q8F 4RNM 4RNN 4RNO 4RU9 4YP3 4YQW 4YR0 4YR2 4YR3 5DG7 5DG8 5DG9 5DGA 5DGB 5DLF 5DLG 5DQG 5DQH 5DQI 5EWE 5EWF 5EWG 5F9L 5F9N 5JUM 5KFA 5KFB 5KFC 5KFD 5KFE 5KFF 5KFG 5KFH 5KFI 5KFJ 5KFK 5KFL 5KFM 5KFN 5KFO 5KFP 5KFQ 5KFR 5KFS 5KFT 5KFU 5KFV 5KFW 5KFX 5KFY 5KFZ 5KG0 5KG1 5KG2 5KG3 5KG4 5KG5 5KG6 5KG7 5L1I 5L1J 5L1K 5L1L 5L9X 6D0M 6D0Z 6M7O 6M7P 6M7T 6M7U 6M7V 6MP3 6MQ8 6MXO 6PL7 6PL8 6PLC 6PZ3 6Q02 6UI2 6UQI
Enriched GO Terms of Interacting Partners?
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