RETN and A2M

Data Source:
BioGRID (two hybrid)

		RETN	A2M
Description		resistin	alpha-2-macroglobulin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome	Extracellular Region Extracellular Space Cytosol Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Hormone Activity Protein Binding	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Tumor Necrosis Factor Binding Calcium-dependent Protein Binding
	Biological Process	Signal Transduction Aging Biological_process Response To Mechanical Stimulus Response To Insulin Neutrophil Degranulation Fat Cell Differentiation Positive Regulation Of Synaptic Transmission Negative Regulation Of Feeding Behavior Positive Regulation Of Progesterone Secretion	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Stem Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Neutrophil degranulation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix Rho GTPase cycle HDL assembly
Drugs			Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Menarche (age at onset) ( 25231870) Resistin levels ( 27664181 24123702 22843503)	Refractive error ( 32231278)
Interacting Genes		3 interacting genes: A2M GPR25 SF3A2	96 interacting genes: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AX HMOX2 HSPA5 HSPB2 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK1 KLK13 KLK2 KLK3 LCAT LEP LINC02582 LONP1 LRP1 LYZ MAST1 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 OGA PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPTIN8 SHBG SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1 UMPS
Entrez ID		56729	2
HPRD ID		05714	00072
Ensembl ID		ENSG00000104918	ENSG00000175899
Uniprot IDs		Q9HD89	P01023
PDB IDs		1LV6	1BV8 2P9R 4ACQ
Enriched GO Terms of Interacting Partners?
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