A2M and CPB2

Data Source:
BioGRID (pull down)

		A2M	CPB2
Description		alpha-2-macroglobulin	carboxypeptidase B2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Tumor Necrosis Factor Binding Calcium-dependent Protein Binding	Metallocarboxypeptidase Activity Zinc Ion Binding
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Stem Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction	Positive Regulation Of Extracellular Matrix Constituent Secretion Proteolysis Blood Coagulation Response To Heat Negative Regulation Of Plasminogen Activation Regulation Of Complement Activation Response To Drug Fibrinolysis Negative Regulation Of Fibrinolysis Cellular Response To Glucose Stimulus Liver Regeneration Negative Regulation Of Hepatocyte Proliferation
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix Rho GTPase cycle HDL assembly	Metabolism of Angiotensinogen to Angiotensins Regulation of Complement cascade
Drugs		Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form	AZD-9684 Prothrombin
Diseases
GWAS		Refractive error ( 32231278)	Blood protein levels ( 29875488 28240269) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355)
Interacting Genes		96 interacting genes: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AX HMOX2 HSPA5 HSPB2 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK1 KLK13 KLK2 KLK3 LCAT LEP LINC02582 LONP1 LRP1 LYZ MAST1 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 OGA PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPTIN8 SHBG SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1 UMPS	6 interacting genes: A2M C5 F2 PLG PZP TINAG
Entrez ID		2	1361
HPRD ID		00072	04374
Ensembl ID		ENSG00000175899	ENSG00000080618
Uniprot IDs		P01023	A0A087WSY5 Q96IY4
PDB IDs		1BV8 2P9R 4ACQ	3D66 3D67 3D68 3LMS 4P10 5HVF 5HVG 5HVH
Enriched GO Terms of Interacting Partners?
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