TRIM39 and BTNL2

Data Source:
BioGRID (proximity labelling technology)

		TRIM39	BTNL2
Description		tripartite motif containing 39	butyrophilin like 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	Signaling Receptor Binding
	Biological Process	Apoptotic Process Mitotic G2 DNA Damage Checkpoint Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Protein Stabilization Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway	Regulation Of Cytokine Production T Cell Receptor Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Butyrophilin (BTN) family interactions
Drugs
Diseases
GWAS		Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Cutaneous lupus erythematosus ( 25827949) Neuroticism ( 29255261)	Adult asthma ( 27611488) Anti-cyclic Citrullinated Peptide Antibody ( 19287509) Apolipoprotein A1 levels ( 32203549) Asthma ( 23028483 21804548 27611488 31619474 29273806) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Childhood steroid-sensitive nephrotic syndrome ( 29903748) Coronary heart disease ( 22751097) Crohn's disease ( 23850713) EGFR mutation-positive lung adenocarcinoma ( 27501781) Fibrinogen levels ( 28107422) Food antigen IgG levels ( 24962563) Frontotemporal dementia ( 24943344) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Height ( 28552196) Hemoglobin ( 29403010) Hepatitis B vaccine response ( 24282030) Hepatitis C induced liver cirrhosis ( 23321320) HIV-1 control ( 20041166) HIV-1 viral setpoint ( 26039976) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 28067908) Knee osteoarthritis ( 20305777) Loneliness (multivariate analysis) ( 27629369) Lung adenocarcinoma ( 22797724) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lymphocyte counts ( 32888494) Marginal zone lymphoma ( 25569183) Medication use (drugs affecting bone structure and mineralization) ( 31015401) Monocyte count ( 32888494) Multiple sclerosis (OCB status) ( 23472185) Primary biliary cholangitis ( 19458352) Prostate cancer ( 23535732) Response to hepatitis B vaccine ( 29534301) Rosacea symptom severity ( 29771307) Sarcoidosis ( 22936702) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Serum alkaline phosphatase levels ( 29403010) SjÃ¶gren's syndrome ( 24097066) Takayasu arteritis ( 25604533) Tuberculosis ( 29036319) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 19915573 28067908 20228799 18836448 21297633 19122664) Vitiligo ( 20410501 21326295) Waist-hip ratio ( 20935629) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		61 interacting genes: APP CACTIN CCNC DCUN1D1 DCX DIP2A EIF4A2 EPHB6 GAMT HINFP KDM1A LMNA LNX1 LXN MED18 MNAT1 MTURN OTUB2 OTUD6A PDLIM5 PLCD4 POLI PRPF3 PSMA6 PSMB1 PSMD9 RAD23A RECK RNF166 SMCO3 TP53 TRIM17 TRIM21 TRIM8 TTC32 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2N UBE2V1 UBE2W UBL5 UBTD1 UBTD2 UBXN1 UBXN6 UBXN7 USP2 USP39 USP5 WDFY3 ZKSCAN4 ZNF26
Entrez ID		56658	56244
HPRD ID		09298	12077
Ensembl ID		ENSG00000204599	ENSG00000204290
Uniprot IDs		A0A024RCP5 A0A024RCR1 Q9HCM9	A0PJV4 F8WBA1 Q9UIR0
PDB IDs		2DID 2DIF 2ECJ
Enriched GO Terms of Interacting Partners?
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