SEPTIN3 and PELI2

Data Source:
BioGRID (two hybrid)

		SEPTIN3	PELI2
Description		septin 3	pellino E3 ubiquitin protein ligase family member 2
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GO Annotations	Cellular Component	Septin Ring Microtubule Cytoskeleton Septin Complex Cell Division Site Neuron Projection Presynapse Presynaptic Cytoskeleton	Cytosol
	Molecular Function	Molecular_function GTPase Activity Protein Binding GTP Binding Identical Protein Binding Molecular Adaptor Activity	Protein Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Cellular Protein Localization Cytoskeleton-dependent Cytokinesis	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Toll Signaling Pathway Regulation Of Toll Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Interleukin-1-mediated Signaling Pathway
Pathways			Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS			Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Body mass index (smoking years interaction) ( 23192594) Body mass index (ever vs never smoking interaction) ( 23192594) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) End-stage kidney disease ( 31178898) Height ( 25133637) Nickel levels ( 26025379) Telomere length ( 21460395)
Interacting Genes		18 interacting genes: CDC37 CHRM3 CKS1B DDIT4L EIF6 LASP1 MAPK6 MOB1A NTAQ1 PELI2 PRKG1 RNF4 RNF8 SDCBP SELENOF SEPTIN1 SLC39A14 WBP2	34 interacting genes: BCL10 CLEC17A CREB3L3 DEAF1 ERO1A FN1 FRYL HNRNPK HYAL2 IRAK1 IRAK2 IRAK4 LAMC3 LTBP3 LZTFL1 MDFI MEOX1 MYD88 NUP62 OR7D2 PCGF2 PICALM RABEP1 REL RMDN3 SEPTIN3 SP4 SRPK1 THAP7 TMEM79 TP53 TP63 TRIM32 UBQLN4
Entrez ID		55964	57161
HPRD ID		10515	17835
Ensembl ID		ENSG00000100167	ENSG00000139946
Uniprot IDs		Q9UH03	Q9H716 Q9HAT8
PDB IDs		3SOP 4Z51 4Z54 6UQQ	3EGA 3EGB
Enriched GO Terms of Interacting Partners?
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