PRKG2 and WDR77

Data Source:
BioGRID (pull down)

		PRKG2	WDR77
Description		protein kinase cGMP-dependent 2	WD repeat domain 77
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GO Annotations	Cellular Component	Cytosol Apical Plasma Membrane Nuclear Membrane	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Methylosome Pole Plasm
	Molecular Function	Protein Kinase Activity CGMP-dependent Protein Kinase Activity ATP Binding CGMP Binding Identical Protein Binding	Protein Binding Methyl-CpG Binding Nuclear Receptor Coactivator Activity
	Biological Process	Protein Phosphorylation Signal Transduction Peptidyl-serine Autophosphorylation Protein Localization To Plasma Membrane Negative Regulation Of Chloride Transport	Spliceosomal SnRNP Assembly Regulation Of Transcription By RNA Polymerase II Pole Plasm Assembly Positive Regulation Of Cell Population Proliferation Positive Regulation Of Transcription, DNA-templated Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Ca2+ pathway cGMP effects cGMP effects RAS processing	snRNP Assembly RMTs methylate histone arginines
Drugs		Fostamatinib
Diseases
GWAS		Blood pressure (smoking interaction) ( 25189868) Body size at age 10 ( 32376654) Height ( 28552196 25282103 19343178 23563607 31562340 18391951) Hip circumference adjusted for BMI ( 25673412) HIV-1 susceptibility ( 22174851) Pubertal anthropometrics ( 23449627) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		7 interacting genes: FBXO25 LASP1 MYLK NEDD4 PLCB3 PTS WDR77	44 interacting genes: AQR BAG2 CDK19 CDK8 CLNS1A CREBBP CTDP1 GLI1 GPKOW H2AC21 HNRNPM LSM3 NKX3-1 PCBP2 PPIL1 PPP1R8 PQBP1 PRKG1 PRKG2 PRMT5 QKI RBM5 RIOK1 SAP30BP SF1 SF3A1 SF3B4 SIRT7 SMAD1 SMYD1 SNRPB SNRPC SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SUZ12 THOC1 TOE1 YWHAB YWHAQ ZMYND19 ZNF207
Entrez ID		5593	79084
HPRD ID		09034	14387
Ensembl ID		ENSG00000138669	ENSG00000116455
Uniprot IDs		A0A140VJM3 B4DLF9 B7ZA25 Q13237	A0A024R0H7 Q9BQA1
PDB IDs		5BV6 5C6C 5C8W 5JIX 5JIZ 6BQ8	4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5 6CKC 6K1S 6RLL 6RLQ 6UXX 6UXY 6V0N 6V0O
Enriched GO Terms of Interacting Partners?
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