PRKG2 and LASP1

Data Source:
HPRD (in vivo, in vitro)

		PRKG2	LASP1
Description		protein kinase cGMP-dependent 2	LIM and SH3 protein 1
Image
GO Annotations	Cellular Component	Cytosol Apical Plasma Membrane Nuclear Membrane	Cytoplasm Focal Adhesion Cortical Actin Cytoskeleton
	Molecular Function	Protein Kinase Activity CGMP-dependent Protein Kinase Activity ATP Binding CGMP Binding Identical Protein Binding	Protein Binding Ion Transmembrane Transporter Activity Cadherin Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Protein Phosphorylation Signal Transduction Peptidyl-serine Autophosphorylation Protein Localization To Plasma Membrane Negative Regulation Of Chloride Transport	Ion Transport Ion Transmembrane Transport
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Ca2+ pathway cGMP effects cGMP effects RAS processing
Drugs		Fostamatinib
Diseases
GWAS		Blood pressure (smoking interaction) ( 25189868) Body size at age 10 ( 32376654) Height ( 28552196 25282103 19343178 23563607 31562340 18391951) Hip circumference adjusted for BMI ( 25673412) HIV-1 susceptibility ( 22174851) Pubertal anthropometrics ( 23449627) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912)
Interacting Genes		7 interacting genes: FBXO25 LASP1 MYLK NEDD4 PLCB3 PTS WDR77	121 interacting genes: ACD ACTA1 ACTB ACTC1 ANKS1A ARHGEF15 ARHGEF16 ARID5A ATXN1 BAG4 BAHD1 BHLHE40 C14orf119 C19orf54 CAMK2A CATSPER1 CDK7 CERCAM CHERP COPS5 CRK CRYBA1 CRYBA2 CSTF2T CTNNA3 CYSRT1 DAZAP2 DMRT3 DNMT1 DOK6 DTX2 EHMT2 EVX2 FAM168A FAM168B FBXO17 FHL3 FOXH1 FXR2 GAS8 GCM2 GOLGA2 GUCD1 HGS HNRNPF HOXA1 INTS11 KRTAP10-8 KRTAP12-4 KRTAP19-3 KRTAP19-4 KRTAP19-6 KRTAP26-1 KRTAP3-2 KRTAP3-3 KRTAP4-2 KRTAP6-2 LENG8 LMO4 LZTS2 MDFI MED25 MGAT5B MKRN3 NOXA1 NUTF2 OTX1 OXER1 PITX1 PLSCR1 POLD1 POT1 POU1F1 PPP1R32 PRKAR2B PRKG1 PRKG2 PRR20A PRR20B PRR20C PRR20D PRR20E PRR35 PSMA3 QRICH1 RBFOX1 RBPMS RBPMS2 REL RHOXF2 RNF38 SEPTIN3 SPAG8 SPRY2 STAT3 TCF4 TEKT3 TEKT4 TEKT5 TERF1 TFG THAP1 TINF2 TLX3 TNS2 TRIM27 TRIP13 UBQLN2 UFSP1 UHRF1 VAC14 VEZF1 VGLL3 VPS37C WWOX YES1 YTHDF1 ZBTB9 ZC2HC1A ZC3H10 ZYX
Entrez ID		5593	3927
HPRD ID		09034	04229
Ensembl ID		ENSG00000138669	ENSG00000002834
Uniprot IDs		A0A140VJM3 B4DLF9 B7ZA25 Q13237	A0A024R1S8 B4DIC4 Q14847
PDB IDs		5BV6 5C6C 5C8W 5JIX 5JIZ 6BQ8	3I35
Enriched GO Terms of Interacting Partners?
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