PRKG2 and PLCB3

Data Source:
HPRD (in vivo)

		PRKG2	PLCB3
Description		protein kinase cGMP-dependent 2	phospholipase C beta 3
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GO Annotations	Cellular Component	Cytosol Apical Plasma Membrane Nuclear Membrane	Nucleus Cytosol Membrane Protein-containing Complex Postsynaptic Cytosol
	Molecular Function	Protein Kinase Activity CGMP-dependent Protein Kinase Activity ATP Binding CGMP Binding Identical Protein Binding	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding Calmodulin Binding Cadherin Binding
	Biological Process	Protein Phosphorylation Signal Transduction Peptidyl-serine Autophosphorylation Protein Localization To Plasma Membrane Negative Regulation Of Chloride Transport	Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Lipid Catabolic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Ca2+ pathway cGMP effects cGMP effects RAS processing	PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors
Drugs		Fostamatinib
Diseases
GWAS		Blood pressure (smoking interaction) ( 25189868) Body size at age 10 ( 32376654) Height ( 28552196 25282103 19343178 23563607 31562340 18391951) Hip circumference adjusted for BMI ( 25673412) HIV-1 susceptibility ( 22174851) Pubertal anthropometrics ( 23449627) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Crohn's disease ( 28067908) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Type 2 diabetes (adjusted for BMI) ( 29632382) Vitiligo ( 27723757) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		7 interacting genes: FBXO25 LASP1 MYLK NEDD4 PLCB3 PTS WDR77	13 interacting genes: CALM3 CAMK2B CAMK2G FOXE1 KRIT1 PARD3 PARD6A PRKG1 PRKG2 RGS12 SLC9A3R2 TRPC3 TRPM7
Entrez ID		5593	5331
HPRD ID		09034	02577
Ensembl ID		ENSG00000138669	ENSG00000149782
Uniprot IDs		A0A140VJM3 B4DLF9 B7ZA25 Q13237	Q01970
PDB IDs		5BV6 5C6C 5C8W 5JIX 5JIZ 6BQ8	3OHM 4GNK 4QJ3 4QJ4 4QJ5
Enriched GO Terms of Interacting Partners?
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