PLCB3 and PRKG2

Data Source:
HPRD (in vivo)

		PLCB3	PRKG2
Description		phospholipase C beta 3	protein kinase cGMP-dependent 2
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GO Annotations	Cellular Component	Nucleus Cytosol Membrane Protein-containing Complex Postsynaptic Cytosol	Cytosol Apical Plasma Membrane Nuclear Membrane
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding Calmodulin Binding Cadherin Binding	Protein Kinase Activity CGMP-dependent Protein Kinase Activity ATP Binding CGMP Binding Identical Protein Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Lipid Catabolic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling	Protein Phosphorylation Signal Transduction Peptidyl-serine Autophosphorylation Protein Localization To Plasma Membrane Negative Regulation Of Chloride Transport
Pathways		PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Ca2+ pathway cGMP effects cGMP effects RAS processing
Drugs			Fostamatinib
Diseases
GWAS		Crohn's disease ( 28067908) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Type 2 diabetes (adjusted for BMI) ( 29632382) Vitiligo ( 27723757) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Blood pressure (smoking interaction) ( 25189868) Body size at age 10 ( 32376654) Height ( 28552196 25282103 19343178 23563607 31562340 18391951) Hip circumference adjusted for BMI ( 25673412) HIV-1 susceptibility ( 22174851) Pubertal anthropometrics ( 23449627) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		13 interacting genes: CALM3 CAMK2B CAMK2G FOXE1 KRIT1 PARD3 PARD6A PRKG1 PRKG2 RGS12 SLC9A3R2 TRPC3 TRPM7	7 interacting genes: FBXO25 LASP1 MYLK NEDD4 PLCB3 PTS WDR77
Entrez ID		5331	5593
HPRD ID		02577	09034
Ensembl ID		ENSG00000149782	ENSG00000138669
Uniprot IDs		Q01970	A0A140VJM3 B4DLF9 B7ZA25 Q13237
PDB IDs		3OHM 4GNK 4QJ3 4QJ4 4QJ5	5BV6 5C6C 5C8W 5JIX 5JIZ 6BQ8
Enriched GO Terms of Interacting Partners?
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