CASP3 and MET

Data Source:
HPRD (in vivo, in vitro)

		CASP3	MET
Description		caspase 3	MET proto-oncogene, receptor tyrosine kinase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Death-inducing Signaling Complex Neuronal Cell Body Membrane Raft	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Cell Surface Integral Component Of Membrane Receptor Complex
	Molecular Function	Protease Binding Aspartic-type Endopeptidase Activity Cysteine-type Endopeptidase Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Death Receptor Binding Protein Binding Peptidase Activity Phospholipase A2 Activator Activity Protein-containing Complex Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Hepatocyte Growth Factor-activated Receptor Activity Protein Binding ATP Binding Semaphorin Receptor Activity Protein Phosphatase Binding Identical Protein Binding
	Biological Process	Luteolysis Response To Hypoxia B Cell Homeostasis Apoptotic DNA Fragmentation Proteolysis Apoptotic Process Cellular Response To DNA Damage Stimulus Axonal Fasciculation Heart Development Sensory Perception Of Sound Learning Or Memory Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Response To UV Response To Glucose Response To X-ray Regulation Of Macroautophagy Protein Processing Cytokine-mediated Signaling Pathway Hippocampus Development Neuron Differentiation Keratinocyte Differentiation Erythrocyte Differentiation Platelet Formation Negative Regulation Of B Cell Proliferation Regulation Of Protein Stability Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Glial Cell Apoptotic Process Response To Tumor Necrosis Factor Response To Nicotine Hippo Signaling Wound Healing Response To Drug Response To Hydrogen Peroxide T Cell Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Response To Amino Acid Positive Regulation Of Neuron Apoptotic Process Cell Fate Commitment Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Activated T Cell Proliferation Response To Antibiotic Neurotrophin TRK Receptor Signaling Pathway Striated Muscle Cell Differentiation Response To Glucocorticoid Neuron Apoptotic Process Anterior Neural Tube Closure Leukocyte Apoptotic Process Cellular Response To Staurosporine Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Execution Phase Of Apoptosis Positive Regulation Of Amyloid-beta Formation	MAPK Cascade Endothelial Cell Morphogenesis Liver Development Phagocytosis Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Negative Regulation Of Autophagy Cell Migration Peptidyl-tyrosine Phosphorylation Neuron Differentiation Pancreas Development Positive Regulation Of Microtubule Polymerization Positive Regulation Of Kinase Activity Negative Regulation Of Rho Protein Signal Transduction Entry Of Bacterium Into Host Cell Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Growth Factor Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Positive Chemotaxis Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Protein Kinase B Signaling Establishment Of Skin Barrier Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Semaphorin-plexin Signaling Pathway Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Positive Regulation Of Endothelial Cell Chemotaxis
Pathways		Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Apoptotic cleavage of cellular proteins SMAC, XIAP-regulated apoptotic response Apoptosis induced DNA fragmentation Degradation of the extracellular matrix Signaling by Hippo NADE modulates death signalling Stimulation of the cell death response by PAK-2p34 Caspase-mediated cleavage of cytoskeletal proteins Apoptotic cleavage of cell adhesion proteins Caspase activation via Dependence Receptors in the absence of ligand Caspase activation via Dependence Receptors in the absence of ligand Other interleukin signaling	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Sema4D mediated inhibition of cell attachment and migration RAF/MAP kinase cascade MET Receptor Activation Negative regulation of MET activity PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates RAS signaling MET activates PI3K/AKT signaling MET activates PTPN11 MET activates PTK2 signaling InlB-mediated entry of Listeria monocytogenes into host cell InlB-mediated entry of Listeria monocytogenes into host cell MET interacts with TNS proteins MET activates RAP1 and RAC1 MET receptor recycling MET activates STAT3 MECP2 regulates neuronal receptors and channels
Drugs		Pamidronic acid Acetylsalicylic acid Minocycline 5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid Emricasan Incadronic acid 2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate 1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE [N-(3-dibenzylcarbamoyl-oxiranecarbonyl)-hydrazino]-acetic acid 4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide Glycyrrhizic acid	K-252a SGX-523 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol AMG-208 1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE Crizotinib Cabozantinib Capmatinib Fostamatinib Tivantinib Brigatinib Amuvatinib
Diseases			Renal cell carcinoma Cholangiocarcinoma Gastric cancer
GWAS		Blood protein levels ( 28240269) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Kawasaki disease ( 33106546)	Blood protein levels ( 30072576) Gamma glutamyl transferase levels ( 29403010) HDL cholesterol levels ( 28334899) Hematocrit ( 28017375) Lung function (FEV1/FVC) ( 30804560) Medication use (beta blocking agents) ( 31015401) Multiple sclerosis (severity) ( 19010793) PR segment ( 24850809) Pulse pressure ( 30578418) Resting heart rate ( 29769521 27798624) Triglyceride levels ( 28334899) Triglycerides ( 24097068) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		157 interacting genes: ACIN1 ADD1 AFP AIFM1 AKAP8 AKT1 APAF1 APP AR ARHGDIA ARHGDIB ARNT ATG4D ATN1 BCAP31 BCAR1 BCL2 BECN1 BID BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BLM BMX BRCA1 CAD CASP10 CASP2 CASP4 CASP6 CASP7 CASP8 CASP9 CAST CDC27 CDC42 CDH1 CDK11B CDKN1A CFLAR COPS6 CRYAB CTNNB1 CTTN DBNL DCC DCTN1 DEDD DFFA DSG3 EIF2AK2 EIF2S1 EIF3J EIF4B EIF4G2 FYN GATA1 GLRX GMNN GOLGA3 GORASP1 GRIPAP1 GSN GZMB HCLS1 HIP1 HMGB1 HNRNPU HSPD1 HSPE1 HTT IL16 IL18 KCNIP3 KRT18 LMNB1 LYN MAP4K1 MAPK8 MAPK8IP3 MAPK9 MAPT MCL1 MDC1 MDM2 MDM4 MEF2A MET MLH1 MYL3 NDUFS1 NEDD4 NFE2L2 NMT2 PAK2 PARG PARP1 PDE10A PDE5A PICALM PIP5K1A PKN1 PKN2 PLA2G4A PLA2G4B PPP3CA PRKCQ PRKCZ PRKDC PSEN1 PSEN2 PSIP1 PSME3 PTBP1 PTGES3 PTMA PXN RABEP1 RAC1 RAD51 RASA1 RB1 RFC1 RNF2 ROCK1 SARS2 SLK SNRNP70 SOCS5 SOHLH1 SP1 SPTAN1 SREBF2 SRF SRP72 STAT1 STK24 STK3 STK4 TFAP2A TGM2 THAP11 TNFSF10 TOP1 TRAF1 TRAF3 UBE4B USO1 VAV1 VIM WEE1 XIAP YWHAE YWHAG ZBTB16	112 interacting genes: ABL2 BAG1 BCAR3 BLK BTK CASP3 CBL CCND2 CD44 CDK4 CDK6 CDKN2B CNR1 CRK CTNNB1 CTTN DAPK3 DCN DNAJA3 EGFR EPHA2 ERBB2 FAS FES FGFR4 FGR FZR1 GAB1 GLIS2 GLMN GRB14 GRB2 GRB7 HCK HGF HGS HSH2D INPP5D INPPL1 ITGB1 ITGB4 ITK KDELR2 LATS2 LCK LYN MAP2K3 MAP2K5 MATK MUC20 MYC NCK1 NCK2 NF2 PCBD2 PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PLXNB1 PTK6 PTPN11 PTPRB PTPRJ RAF1 RANBP10 RANBP9 RASA1 RASSF1 SH2B1 SH2B2 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3C SH3BP2 SHB SHC1 SHC2 SHC3 SHC4 SHD SLA2 SMC1A SNAPIN SNX2 SOCS1 SOCS2 SOCS3 SOCS5 SOCS6 SPSB1 SRC STAP1 STAT3 STK11 SYK TEC TERT TNS1 TNS2 TNS3 TNS4 TP53 TXK VAV1 VAV2 VAV3 YES1 ZAP70
Entrez ID		836	4233
HPRD ID		02799	01280
Ensembl ID		ENSG00000164305	ENSG00000105976
Uniprot IDs		P42574	A0A024R728 A0A024R759 B4DLF5 E6Y365 P08581
PDB IDs		1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL 2CNN 2CNO 2DKO 2H5I 2H5J 2H65 2J30 2J31 2J32 2J33 2XYG 2XYH 2XYP 2XZD 2XZT 2Y0B 3DEH 3DEI 3DEJ 3DEK 3EDQ 3GJQ 3GJR 3GJS 3GJT 3H0E 3ITN 3KJF 3PCX 3PD0 3PD1 4DCJ 4DCO 4DCP 4EHA 4EHD 4EHF 4EHH 4EHK 4EHL 4EHN 4JJE 4JQY 4JQZ 4JR0 4PRY 4PS0 4QTX 4QTY 4QU0 4QU5 4QU8 4QU9 4QUA 4QUB 4QUD 4QUE 4QUG 4QUH 4QUI 4QUJ 4QUL 5I9B 5I9T 5IAB 5IAE 5IAG 5IAJ 5IAK 5IAN 5IAR 5IAS 5IBC 5IBP 5IBR 5IC4	1FYR 1R0P 1R1W 1SHY 1SSL 1UX3 2G15 2RFN 2RFS 2UZX 2UZY 2WD1 2WGJ 2WKM 3A4P 3BUX 3C1X 3CCN 3CD8 3CE3 3CTH 3CTJ 3DKC 3DKF 3DKG 3EFJ 3EFK 3F66 3F82 3I5N 3L8V 3LQ8 3Q6U 3Q6W 3QTI 3R7O 3RHK 3U6H 3U6I 3VW8 3ZBX 3ZC5 3ZCL 3ZXZ 3ZZE 4AOI 4AP7 4DEG 4DEH 4DEI 4EEV 4GG5 4GG7 4IWD 4K3J 4KNB 4MXC 4O3T 4O3U 4R1V 4R1Y 4XMO 4XYF 5DG5 5EOB 5EYC 5EYD 5HLW 5HNI 5HO6 5HOA 5HOR 5HTI 5LSP 5T3Q 5UAB 5UAD 5YA5 6GCU 6I04 6SD9 6SDC 6SDD 6SDE 6UBW
Enriched GO Terms of Interacting Partners?
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