ADCY5 and ADCY2

Data Source:
HPRD (in vitro)

		ADCY5	ADCY2
Description		adenylate cyclase 5	adenylate cyclase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cilium Integral Component Of Membrane Intermediate Filament Cytoskeleton	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Dendrite Membrane Raft
	Molecular Function	Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Metal Ion Binding Scaffold Protein Binding	Magnesium Ion Binding Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Manganese Ion Binding
	Biological Process	G Protein-coupled Adenosine Receptor Signaling Pathway Renal Water Homeostasis CAMP Biosynthetic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Locomotory Behavior Activation Of Protein Kinase A Activity Neuromuscular Process Controlling Balance Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cellular Response To Glucagon Stimulus Cellular Response To Forskolin	Renal Water Homeostasis CAMP Biosynthetic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway CAMP-mediated Signaling Activation Of Protein Kinase A Activity Cellular Response To Glucagon Stimulus Cellular Response To Forskolin
Pathways		Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis	Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis
Drugs		Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE Aurothioglucose	Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE Aurothioglucose
Diseases
GWAS		Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Birth weight ( 23202124 31043758 27680694 20372150) Body mass index ( 25673413) Chronic kidney disease ( 26420894) Chronic obstructive pulmonary disease ( 30804561) Chronotype ( 30696823) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Gestational age at birth (maternal effect) ( 28877031) Glycated hemoglobin levels ( 28898252) Glycemic traits (pleiotropy) ( 31021400) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Homeostasis model assessment of beta-cell function ( 20081858) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) PR interval ( 32439900) Pulse pressure ( 30224653) Refractive error ( 32231278) Total cholesterol levels ( 29083408) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 22885922 24509480 30054458 22693455 29358691 30297969 28254843 26818947 32499647 28869590) White blood cell count ( 32888494)	Anxiety and stress-related disorders ( 31116379) Atorvastatin-induced myopathy ( 31220337) Bipolar disorder ( 24618891 31043756) Bipolar disorder (age of onset <21) or attention deficit hyperactivity disorder ( 27890468) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Bipolar I disorder ( 31043756) Capecitabine sensitivity ( 22864933) Coffee consumption ( 31046077) Cognitive decline rate in late mild cognitive impairment ( 26252872) Food addiction ( 27106561) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Oropharynx cancer ( 27749845) Pars opercularis volume ( 31530798) Plasma factor VII activating protease levels ( 30070759) Posterior-cingulate cortex volume ( 31530798) Smoking status (heavy vs never) ( 26423011) Visceral fat ( 22589738)
Interacting Genes		7 interacting genes: ADCY2 GNAI1 GNAS PRKACA PRKCA PRKCZ RGS2	6 interacting genes: ADCY1 ADCY5 DRD4 F2RL1 GNAS GNG2
Entrez ID		111	108
HPRD ID		08973	00052
Ensembl ID		ENSG00000173175	ENSG00000078295
Uniprot IDs		A0A384P5Q5 B3KWA8 B7Z2C7 O95622	Q08462 Q71UM8
PDB IDs
Enriched GO Terms of Interacting Partners?
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