VPS11 and VPS33A

Data Source:
HPRD (in vivo)

		VPS11	VPS33A
Description		VPS11 core subunit of CORVET and HOPS complexes	VPS33A core subunit of CORVET and HOPS complexes
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Clathrin-coated Vesicle Endocytic Vesicle HOPS Complex Late Endosome Membrane	Lysosome Lysosomal Membrane Early Endosome Late Endosome Autophagosome AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Late Endosome Membrane CORVET Complex Perinuclear Region Of Cytoplasm Clathrin Complex
	Molecular Function	Nucleotide Binding Protein Binding Protein Domain Specific Binding Syntaxin Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome Organization Vacuole Organization Endosome To Lysosome Transport Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Regulation Of Organelle Assembly Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Early Endosome To Late Endosome Transport	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Endosome To Lysosome Transport Vesicle-mediated Transport Platelet Formation Melanosome Localization Lysosome Localization Regulation Of Lysosomal Lumen PH Regulation Of Developmental Pigmentation Autophagosome Maturation
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 29273807) Coronary artery disease ( 29212778 33020668) HDL cholesterol levels ( 32203549) Plateletcrit ( 32888494)
Interacting Genes		33 interacting genes: BCAR1 BMI1 ECPAS EZR GGA3 KDM1A KRTAP10-3 KRTAP10-8 LRSAM1 LSM1 MARK3 MON1B MSN RAB7A RDX RILP RNF181 STX1A STX6 STX7 STX8 TFAP2B TRIM32 TSG101 UBE2D2 UBE2L3 UBE2U UVRAG VPS16 VPS18 VPS33A VPS39 VPS45	7 interacting genes: MON1A MON1B ROPN1 TNKS VPS11 VPS16 VPS18
Entrez ID		55823	65082
HPRD ID		12258	15651
Ensembl ID		ENSG00000160695	ENSG00000139719
Uniprot IDs		A0A087WXL6 B7Z879 Q9H270	Q96AX1
PDB IDs			4BX8 4BX9
Enriched GO Terms of Interacting Partners?
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