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VPS11 and UBE2U
Data Source:
BioGRID
(two hybrid)
VPS11
UBE2U
Description
VPS11 core subunit of CORVET and HOPS complexes
ubiquitin conjugating enzyme E2 U
Image
No pdb structure
GO Annotations
Cellular Component
Lysosome
Lysosomal Membrane
Endosome
Early Endosome
Late Endosome
Autophagosome
Clathrin-coated Vesicle
Endocytic Vesicle
HOPS Complex
Late Endosome Membrane
HULC Complex
Molecular Function
Nucleotide Binding
Protein Binding
Protein Domain Specific Binding
Syntaxin Binding
Protein-macromolecule Adaptor Activity
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Protein Binding
ATP Binding
Ubiquitin Conjugating Enzyme Activity
Biological Process
Intracellular Protein Transport
Vesicle Docking Involved In Exocytosis
Autophagy
Endosome Organization
Vacuole Organization
Endosome To Lysosome Transport
Protein Ubiquitination
Regulation Of Protein Stability
Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Endosomal Vesicle Fusion
Regulation Of SNARE Complex Assembly
Regulation Of Organelle Assembly
Positive Regulation Of Cellular Protein Catabolic Process
Positive Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Early Endosome To Late Endosome Transport
Protein Polyubiquitination
DNA Repair
Histone Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Adult body size (
32376654
)
Body mass index (
29273807
)
Coronary artery disease (
29212778
33020668
)
HDL cholesterol levels (
32203549
)
Plateletcrit (
32888494
)
Severe bacterial meningitis (
31092817
)
Interacting Genes
33 interacting genes:
BCAR1
BMI1
ECPAS
EZR
GGA3
KDM1A
KRTAP10-3
KRTAP10-8
LRSAM1
LSM1
MARK3
MON1B
MSN
RAB7A
RDX
RILP
RNF181
STX1A
STX6
STX7
STX8
TFAP2B
TRIM32
TSG101
UBE2D2
UBE2L3
UBE2U
UVRAG
VPS16
VPS18
VPS33A
VPS39
VPS45
68 interacting genes:
ANAPC11
BARD1
BFAR
CADPS2
CBL
CGRRF1
DTX1
DZIP3
GOLGA2
KAT6A
MDM2
MIB1
MIB2
MID2
MKRN3
MUL1
PCGF1
PCGF2
PCGF6
PJA1
PML
RBCK1
RNF10
RNF11
RNF113A
RNF113B
RNF114
RNF125
RNF139
RNF14
RNF144B
RNF150
RNF166
RNF17
RNF170
RNF181
RNF2
RNF25
RNF26
RNF41
RNF5
RNFT1
SYVN1
TRAIP
TRIM15
TRIM2
TRIM23
TRIM24
TRIM27
TRIM28
TRIM3
TRIM32
TRIM34
TRIM35
TRIM37
TRIM38
TRIM46
TRIM47
TRIM5
TRIM54
TRIM63
TRIM65
TRIM68
TRIM74
UBA1
VPS11
VPS41
ZSWIM2
Entrez ID
55823
148581
HPRD ID
12258
14599
Ensembl ID
ENSG00000160695
ENSG00000177414
Uniprot IDs
A0A087WXL6
B7Z879
Q9H270
A0A140VJY9
Q5VVX9
PDB IDs
1YRV
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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