PRKCG and STXBP1

Data Source:
HPRD (in vitro, in vivo)

		PRKCG	STXBP1
Description		protein kinase C gamma	syntaxin binding protein 1
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GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Cell-cell Junction Postsynaptic Density Dendrite Calyx Of Held Perinuclear Region Of Cytoplasm Synaptic Membrane Presynaptic Cytosol Postsynaptic Cytosol	Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Secretory Granule Axon Platelet Alpha Granule Protein-containing Complex Phagocytic Vesicle Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding	SNARE Binding RNA Binding Protein Binding Syntaxin-1 Binding Protein Kinase Binding Protein Domain Specific Binding Syntaxin Binding Identical Protein Binding Phospholipase Binding Protein N-terminus Binding
	Biological Process	Protein Phosphorylation Chemical Synaptic Transmission Learning Or Memory Chemosensory Behavior Phosphorylation Peptidyl-serine Phosphorylation Platelet Activation Negative Regulation Of Protein Ubiquitination Regulation Of Response To Food Positive Regulation Of Mismatch Repair Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Regulation Of Circadian Rhythm Response To Morphine Negative Regulation Of Neuron Apoptotic Process Protein Autophosphorylation Response To Pain Rhythmic Process Regulation Of Phagocytosis Innervation Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Proteasomal Protein Catabolic Process Response To Psychosocial Stress Regulation Of Synaptic Vesicle Exocytosis	Platelet Degranulation Developmental Process Involved In Reproduction Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Neuromuscular Synaptic Transmission Axon Target Recognition Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Priming Synaptic Vesicle Maturation Vesicle-mediated Transport Negative Regulation Of Protein-containing Complex Assembly Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Negative Regulation Of Synaptic Transmission, GABAergic Response To Estradiol SNARE Complex Assembly Regulation Of SNARE Complex Assembly Positive Regulation Of Mast Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Calcium Ion-dependent Exocytosis Protein Stabilization Long-term Synaptic Depression Platelet Aggregation Cellular Response To Interferon-gamma Protein Localization To Plasma Membrane Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Vesicle Docking Positive Regulation Of Glutamate Secretion, Neurotransmission Regulation Of Acrosomal Vesicle Exocytosis
Pathways		Calmodulin induced events Disinhibition of SNARE formation Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events WNT5A-dependent internalization of FZD4 Response to elevated platelet cytosolic Ca2+	Regulation of insulin secretion Neurexins and neuroligins
Drugs		Tamoxifen Fostamatinib
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)	Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS			Body size at age 10 ( 32376654) Whole brain grey matter density ( 31530798)
Interacting Genes		64 interacting genes: AFAP1 ANXA7 APP ARHGEF25 ARHGEF7 CASR CCHCR1 CD5 CDC42 CHAT CTNNB1 CYTH2 DAB2 DDX58 DNAJC5 DVL2 EIF4E EPHB1 EXOC5 FBXO7 GABRA1 GABRA4 GFAP GJA1 GJA3 GRIA4 GRIN1 GRIN2B GRIN2D GRK2 GRM5 GSK3A HABP4 HSPA4 IRS1 ITGB2 MAPT MARK4 NOXA1 NRGN NUMB PA2G4 PARD3 PARD6A PARD6B PDLIM5 PEBP1 PICK1 PNMA1 PPP1R14A RANBP10 RGS2 SCN3A SDC2 SMURF1 STXBP1 TIAM1 TOP2A TRIM5 UBE2T VTN YWHAB YWHAE YWHAG	34 interacting genes: APBA1 APBA2 APP BRME1 CDK5 CDK5R1 CENPP DOC2A DOC2B HGS MAPK1 MAPT MEOX2 MTDH MTNR1A NEFH NEFM PLD1 PLD2 PRKCA PRKCB PRKCG SPICE1 SPTBN1 SQSTM1 STX19 STX1A STX1B STX2 STX3 STX5 SYTL4 TRIM38 USO1
Entrez ID		5582	6812
HPRD ID		01502	04235
Ensembl ID		ENSG00000126583	ENSG00000136854
Uniprot IDs		B2R5T1 B7Z3W6 P05129	P61764
PDB IDs		2E73 2UZP	6L03
Enriched GO Terms of Interacting Partners?
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