PRKCG and AFAP1

Data Source:
HPRD (in vitro)

		PRKCG	AFAP1
Description		protein kinase C gamma	actin filament associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Cell-cell Junction Postsynaptic Density Dendrite Calyx Of Held Perinuclear Region Of Cytoplasm Synaptic Membrane Presynaptic Cytosol Postsynaptic Cytosol	Cytosol Focal Adhesion Actin Cytoskeleton
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding	Actin Binding SH3 Domain Binding SH2 Domain Binding
	Biological Process	Protein Phosphorylation Chemical Synaptic Transmission Learning Or Memory Chemosensory Behavior Phosphorylation Peptidyl-serine Phosphorylation Platelet Activation Negative Regulation Of Protein Ubiquitination Regulation Of Response To Food Positive Regulation Of Mismatch Repair Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Regulation Of Circadian Rhythm Response To Morphine Negative Regulation Of Neuron Apoptotic Process Protein Autophosphorylation Response To Pain Rhythmic Process Regulation Of Phagocytosis Innervation Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Proteasomal Protein Catabolic Process Response To Psychosocial Stress Regulation Of Synaptic Vesicle Exocytosis	Regulation Of Signal Transduction Regulation Of Cytoskeleton Organization
Pathways		Calmodulin induced events Disinhibition of SNARE formation Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events WNT5A-dependent internalization of FZD4 Response to elevated platelet cytosolic Ca2+
Drugs		Tamoxifen Fostamatinib
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS			Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cadmium levels ( 26025379) Cortical surface area (MOSTest) ( 32665545) Diverticular disease ( 30177863) Glaucoma ( 30104761 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935 25173105 27623284 29452408 25861811) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Intraocular pressure ( 29617998 29785010 31959993 30054594 29235454) Lung function (FEV1/FVC) ( 30061609 30804560) Medication use (antiglaucoma preparations and miotics) ( 31015401) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 27618447) Response to antidepressants (symptom improvement) ( 29160301) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		64 interacting genes: AFAP1 ANXA7 APP ARHGEF25 ARHGEF7 CASR CCHCR1 CD5 CDC42 CHAT CTNNB1 CYTH2 DAB2 DDX58 DNAJC5 DVL2 EIF4E EPHB1 EXOC5 FBXO7 GABRA1 GABRA4 GFAP GJA1 GJA3 GRIA4 GRIN1 GRIN2B GRIN2D GRK2 GRM5 GSK3A HABP4 HSPA4 IRS1 ITGB2 MAPT MARK4 NOXA1 NRGN NUMB PA2G4 PARD3 PARD6A PARD6B PDLIM5 PEBP1 PICK1 PNMA1 PPP1R14A RANBP10 RGS2 SCN3A SDC2 SMURF1 STXBP1 TIAM1 TOP2A TRIM5 UBE2T VTN YWHAB YWHAE YWHAG	9 interacting genes: ACTA1 ACTC1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ SRC
Entrez ID		5582	60312
HPRD ID		01502	09747
Ensembl ID		ENSG00000126583	ENSG00000196526
Uniprot IDs		B2R5T1 B7Z3W6 P05129	Q6ZRV0 Q8N556
PDB IDs		2E73 2UZP
Enriched GO Terms of Interacting Partners?
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