PRKCG and GABRA4

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		PRKCG	GABRA4
Description		protein kinase C gamma	gamma-aminobutyric acid type A receptor subunit alpha4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Cell-cell Junction Postsynaptic Density Dendrite Calyx Of Held Perinuclear Region Of Cytoplasm Synaptic Membrane Presynaptic Cytosol Postsynaptic Cytosol	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Membrane Chloride Channel Complex Neuron Projection Synapse Postsynapse GABA-ergic Synapse Integral Component Of Postsynaptic Specialization Membrane GABA-A Receptor Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding	GABA-A Receptor Activity Inhibitory Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity Benzodiazepine Receptor Activity GABA-gated Chloride Ion Channel Activity Neurotransmitter Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Protein Phosphorylation Chemical Synaptic Transmission Learning Or Memory Chemosensory Behavior Phosphorylation Peptidyl-serine Phosphorylation Platelet Activation Negative Regulation Of Protein Ubiquitination Regulation Of Response To Food Positive Regulation Of Mismatch Repair Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Regulation Of Circadian Rhythm Response To Morphine Negative Regulation Of Neuron Apoptotic Process Protein Autophosphorylation Response To Pain Rhythmic Process Regulation Of Phagocytosis Innervation Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Proteasomal Protein Catabolic Process Response To Psychosocial Stress Regulation Of Synaptic Vesicle Exocytosis	Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Ion Transmembrane Transport Regulation Of Membrane Potential Nervous System Process Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Chloride Transmembrane Transport
Pathways		Calmodulin induced events Disinhibition of SNARE formation Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events WNT5A-dependent internalization of FZD4 Response to elevated platelet cytosolic Ca2+	GABA receptor activation GABA receptor activation
Drugs		Tamoxifen Fostamatinib	Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Butalbital Phenytoin Etomidate Talbutal Talbutal Pentobarbital Pentobarbital Clobazam Meprobamate Meprobamate Eszopiclone Alprazolam Secobarbital Metharbital Metharbital Chlordiazepoxide Amoxapine Adinazolam Lamotrigine Thiopental Medroxyprogesterone acetate Clorazepic acid Acamprosate Midazolam Flurazepam Isoflurane Primidone Primidone Halazepam Propofol Diazepam Oxazepam Methylphenobarbital Triazolam Ethanol Methoxyflurane Memantine Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Glutethimide Barbital Camazepam Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Delorazepam Flunitrazepam Ethyl loflazepate Cloxazolam Bromazepam Clotiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Ganaxolone Brotizolam Stiripentol Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Benzodiazepine Pinazepam Medazepam Loprazolam Doxefazepam Lormetazepam Nordazepam Oxazepam acetate Cinazepam Bentazepam Mexazolam
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS			Cognitive decline (age-related) ( 28078323) Polycystic ovary syndrome ( 30343302) Type 2 diabetes ( 23937595)
Interacting Genes		64 interacting genes: AFAP1 ANXA7 APP ARHGEF25 ARHGEF7 CASR CCHCR1 CD5 CDC42 CHAT CTNNB1 CYTH2 DAB2 DDX58 DNAJC5 DVL2 EIF4E EPHB1 EXOC5 FBXO7 GABRA1 GABRA4 GFAP GJA1 GJA3 GRIA4 GRIN1 GRIN2B GRIN2D GRK2 GRM5 GSK3A HABP4 HSPA4 IRS1 ITGB2 MAPT MARK4 NOXA1 NRGN NUMB PA2G4 PARD3 PARD6A PARD6B PDLIM5 PEBP1 PICK1 PNMA1 PPP1R14A RANBP10 RGS2 SCN3A SDC2 SMURF1 STXBP1 TIAM1 TOP2A TRIM5 UBE2T VTN YWHAB YWHAE YWHAG	3 interacting genes: APP DGAT1 PRKCG
Entrez ID		5582	2557
HPRD ID		01502	08839
Ensembl ID		ENSG00000126583	ENSG00000109158
Uniprot IDs		B2R5T1 B7Z3W6 P05129	P48169 X5D7F5
PDB IDs		2E73 2UZP
Enriched GO Terms of Interacting Partners?
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