TRIM36 and EIF4A2

Data Source:
BioGRID (two hybrid)

		TRIM36	EIF4A2
Description		tripartite motif containing 36	eukaryotic translation initiation factor 4A2
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Cytosol Cytoskeleton	Cytosol Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Alpha-tubulin Binding	RNA Binding RNA Helicase Activity Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding ATPase Activity
	Biological Process	Protein Polyubiquitination Mitotic Cytokinesis Spindle Organization Acrosome Reaction Regulation Of Cell Cycle Regulation Of Microtubule Cytoskeleton Organization	Cytoplasmic Translational Initiation Translational Initiation Regulation Of Translational Initiation Viral Process Negative Regulation Of RNA-directed 5'-3' RNA Polymerase Activity Cellular Response To Leukemia Inhibitory Factor
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878 28739976 27618452 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Left-handedness ( 32989287) Malaria ( 31844061) Mean arterial pressure ( 30487518) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 27841878 28739976 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858)
Interacting Genes		11 interacting genes: BTRC EIF4A2 GLRX3 GRB7 TRAF3IP3 UBC UBE2D2 UBE2H ZMAT2 ZNF417 ZNF587	23 interacting genes: BRCA1 CLNS1A DPPA4 ECT2 EIF4G1 EIF4G2 GOLGA2 HSPB2 IPO11 LINC01554 MCPH1 MDFI NEK2 PDCD4 PFDN1 PIH1D2 SLC16A9 SSX2IP SUMO2 TK1 TRIM36 TRIM39 ZNF620
Entrez ID		55521	1974
HPRD ID		15554	03062
Ensembl ID		ENSG00000152503	ENSG00000156976
Uniprot IDs		E9PBG3 Q4R1Q4 Q9NQ86	Q14240
PDB IDs			3BOR
Enriched GO Terms of Interacting Partners?
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