TRIM36 and UBE2H

Data Source:
BioGRID (two hybrid)

		TRIM36	UBE2H
Description		tripartite motif containing 36	ubiquitin conjugating enzyme E2 H
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Cytosol Cytoskeleton	Nucleus Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Alpha-tubulin Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Mitotic Cytokinesis Spindle Organization Acrosome Reaction Regulation Of Cell Cycle Regulation Of Microtubule Cytoskeleton Organization	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878 28739976 27618452 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Left-handedness ( 32989287) Malaria ( 31844061) Mean arterial pressure ( 30487518) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 27841878 28739976 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858)	Estimated glomerular filtration rate ( 31152163 31451708) Lymphocyte counts ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Response to antidepressants and depression ( 27622933) White blood cell count ( 32888494)
Interacting Genes		11 interacting genes: BTRC EIF4A2 GLRX3 GRB7 TRAF3IP3 UBC UBE2D2 UBE2H ZMAT2 ZNF417 ZNF587	68 interacting genes: BRAP BYSL CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GOLGA2 H2AC18 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MKRN3 NEURL1 NHLRC1 POLL POLM PRKN PSME3 RAG1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 TLE5 TRAIP TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 TRIM72 UBA1 UBASH3B UBOX5 UBR2 UBR3
Entrez ID		55521	7328
HPRD ID		15554	03052
Ensembl ID		ENSG00000152503	ENSG00000186591
Uniprot IDs		E9PBG3 Q4R1Q4 Q9NQ86	A0A3B3IU20 A4D1L5 P62256
PDB IDs			2Z5D
Enriched GO Terms of Interacting Partners?
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