YOD1 and MKRN1

Data Source:
BioGRID (two hybrid)

		YOD1	MKRN1
Description		YOD1 deubiquitinase	makorin ring finger protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cellular_component Cytosol
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Lys63-specific Deubiquitinase Activity Ubiquitinyl Hydrolase Activity Lys48-specific Deubiquitinase Activity	RNA Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Macroautophagy Protein Deubiquitination Protein Phosphopantetheinylation Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Protein K29-linked Deubiquitination Protein K11-linked Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Protein K27-linked Deubiquitination Protein K33-linked Deubiquitination	Protein Polyubiquitination Protein Ubiquitination
Pathways		Ovarian tumor domain proteases	AKT phosphorylates targets in the cytosol Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Systolic blood pressure ( 28234671)	General risk tolerance (MTAG) ( 30643258) Gut microbiota relative abundance (unassigned genus belonging to family Lachnospiraceae) ( 33208821) Immature fraction of reticulocytes ( 32888494) Number of sexual partners ( 30643258)
Interacting Genes		30 interacting genes: BIRC3 DAZAP2 DDIT4L FAM168A INCA1 LMO2 MKRN1 NEDD4 NGRN PLEKHB2 PSMA7 RFC2 RIPK1 RNF216 SHARPIN SNCA SPART TP53BP2 TRAF6 TRIM54 TRIM55 TRIM63 TRIM8 UBC UBE3A UBXN6 USP15 USP21 VCP ZFP57	23 interacting genes: APC ASH2L BYSL CSNK1G1 DAXX DUSP23 EXOSC8 FADD FAM161A MAP1LC3B MTURN NAA10 OTUB2 RAD23A RAD23B SDCBP SLC13A1 UBASH3A UBE2D1 UBE2D3 UBE2D4 UBE2W YOD1
Entrez ID		55432	23608
HPRD ID		10312	09673
Ensembl ID		ENSG00000180667	ENSG00000133606
Uniprot IDs		Q5VVQ6	Q9UHC7
PDB IDs		4BOQ 4BOS 4BOZ
Enriched GO Terms of Interacting Partners?
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