YOD1 and SPART

Data Source:
BioGRID (two hybrid)

		YOD1	SPART
Description		YOD1 deubiquitinase	spartin
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Mitochondrial Outer Membrane Lipid Droplet Cytosol Plasma Membrane Midbody Synapse
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Lys63-specific Deubiquitinase Activity Ubiquitinyl Hydrolase Activity Lys48-specific Deubiquitinase Activity	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Macroautophagy Protein Deubiquitination Protein Phosphopantetheinylation Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Protein K29-linked Deubiquitination Protein K11-linked Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Protein K27-linked Deubiquitination Protein K33-linked Deubiquitination	Abscission Negative Regulation Of BMP Signaling Pathway Lipid Droplet Organization Negative Regulation Of Collateral Sprouting In Absence Of Injury Neuromuscular Process Cell Division Regulation Of Mitochondrial Membrane Potential Adipose Tissue Development
Pathways		Ovarian tumor domain proteases
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Systolic blood pressure ( 28234671)
Interacting Genes		30 interacting genes: BIRC3 DAZAP2 DDIT4L FAM168A INCA1 LMO2 MKRN1 NEDD4 NGRN PLEKHB2 PSMA7 RFC2 RIPK1 RNF216 SHARPIN SNCA SPART TP53BP2 TRAF6 TRIM54 TRIM55 TRIM63 TRIM8 UBC UBE3A UBXN6 USP15 USP21 VCP ZFP57	22 interacting genes: APP APPL1 DESI2 EPN2 EPS15 GPR35 ITCH MAP3K1 OTUB2 OTUD7B OTULIN PLIN3 PRKAR1A RABGEF1 SMURF1 SMURF2 TUBA1A UBAC1 USP5 WWP2 YOD1 ZFYVE9
Entrez ID		55432	23111
HPRD ID		10312	06170
Ensembl ID		ENSG00000180667	ENSG00000133104
Uniprot IDs		Q5VVQ6	A0A024RDV9 Q8N0X7
PDB IDs		4BOQ 4BOS 4BOZ	2DL1 4U7I
Enriched GO Terms of Interacting Partners?
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