AUP1 and GPR35

Data Source:
BioGRID (two hybrid)

		AUP1	GPR35
Description		AUP1 lipid droplet regulating VLDL assembly factor	G protein-coupled receptor 35
Image			No pdb structure
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase ERAD-L Complex Autophagosome Endoplasmic Reticulum Lipid Droplet Membrane Integral Component Of Endoplasmic Reticulum Membrane Cytoplasmic Vesicle Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin-protein Transferase Activator Activity	G Protein-coupled Receptor Activity C-X-C Chemokine Receptor Activity
	Biological Process	Response To Virus Viral Process Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Lipid Droplet Organization Regulation Of Catalytic Activity Lipophagy ER-associated Misfolded Protein Catabolic Process Lipid Droplet Formation Protein Localization To Lipid Droplet	Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Chemokine-mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Neuronal Action Potential
Pathways			Class A/1 (Rhodopsin-like receptors)
Drugs			Furosemide Pyrantel Kynurenic Acid
Diseases
GWAS			Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 25489960) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Pediatric autoimmune diseases ( 26301688) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403) Ulcerative colitis ( 28067908 21297633)
Interacting Genes		10 interacting genes: GPR35 ITGA1 ITGA2 ITGA2B ITGA5 ITGAM ITGAV RNF11 UBC UBE2G2	59 interacting genes: ABHD14A ADGRB1 AIG1 APH1A ATP1A1 ATP2C1 AUP1 B3GAT3 B4GALT2 BNIP1 CANX CD81 CH25H CMTM3 CRHR2 ERGIC3 FLRT1 FTH1 GHITM GJC2 GPR146 GPR161 HLA-A KCNJ4 KDELR1 LSS MCOLN1 MSMO1 NPC1 NSDHL OSTC PLD3 PLLP PLXDC1 PPP1R3F RTN3 RTN4 SCARB1 SDHD SELENOK SLC15A4 SLC2A1 SLC31A2 SLC37A1 SLC37A4 SLC45A4 SLC8A2 SLC9A7 SPART SYNGR2 SYT11 TMEM161A TMEM94 TSPAN7 VPS25 VTI1B YIF1B ZDHHC3 ZFAND1
Entrez ID		550	2859
HPRD ID		03892	16003
Ensembl ID		ENSG00000115307	ENSG00000178623
Uniprot IDs		Q9Y679	A8K2J1 B2RA17 Q9HC97
PDB IDs		2EKF
Enriched GO Terms of Interacting Partners?
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