AUP1 and ITGAV

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		AUP1	ITGAV
Description		AUP1 lipid droplet regulating VLDL assembly factor	integrin subunit alpha V
Image
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase ERAD-L Complex Autophagosome Endoplasmic Reticulum Lipid Droplet Membrane Integral Component Of Endoplasmic Reticulum Membrane Cytoplasmic Vesicle Extracellular Exosome	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane Integrin Alphav-beta3 Complex Integrin Alphav-beta5 Complex Integrin Alphav-beta6 Complex Integrin Alphav-beta8 Complex Specific Granule Membrane Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Alphav-beta3 Integrin-HMGB1 Complex Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin-protein Transferase Activator Activity	Virus Receptor Activity Opsonin Binding Fibronectin Binding Protease Binding Protein Kinase C Binding Integrin Binding Voltage-gated Calcium Channel Activity Protein Binding Coreceptor Activity Fibroblast Growth Factor Binding C-X3-C Chemokine Binding Insulin-like Growth Factor I Binding Neuregulin Binding Metal Ion Binding Transforming Growth Factor Beta Binding Extracellular Matrix Binding Extracellular Matrix Protein Binding
	Biological Process	Response To Virus Viral Process Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Lipid Droplet Organization Regulation Of Catalytic Activity Lipophagy ER-associated Misfolded Protein Catabolic Process Lipid Droplet Formation Protein Localization To Lipid Droplet	Angiogenesis Vasculogenesis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Extracellular Matrix Organization Positive Regulation Of Cell Migration Cell-substrate Adhesion Negative Regulation Of Lipid Transport Cell Adhesion Mediated By Integrin Positive Regulation Of Osteoblast Proliferation Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Apolipoprotein A-I-mediated Signaling Pathway Apoptotic Cell Clearance Neutrophil Degranulation Positive Regulation Of Cell Adhesion Viral Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Lipoprotein Metabolic Process Regulation Of Phagocytosis Leukocyte Migration Negative Chemotaxis ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Transforming Growth Factor Beta Production Entry Into Host Cell By A Symbiont-containing Vacuole Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Transforming Growth Factor Beta Activation Negative Regulation Of Low-density Lipoprotein Receptor Activity Negative Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Cross-presentation of particulate exogenous antigens (phagosomes) Elastic fibre formation PECAM1 interactions Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Syndecan interactions Syndecan interactions ECM proteoglycans VEGFA-VEGFR2 Pathway Signal transduction by L1 Neutrophil degranulation
Drugs			Antithymocyte immunoglobulin (rabbit) Levothyroxine
Diseases
GWAS			Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Left-handedness ( 32989287) Lung function (FEV1/FVC) ( 30804560) Microalbuminuria ( 26631737) Urinary albumin-to-creatinine ratio ( 26631737) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)
Interacting Genes		10 interacting genes: GPR35 ITGA1 ITGA2 ITGA2B ITGA5 ITGAM ITGAV RNF11 UBC UBE2G2	33 interacting genes: ADAM9 ANGPTL3 AUP1 AZGP1 CALR CCN1 CCN3 CD47 EDIL3 F2R ICAM4 ITGB1 ITGB3 ITGB5 ITGB6 ITGB8 L1CAM LGALS3BP MAPK3 MMP14 MMP2 NID1 P2RY2 PAK4 PDGFRA PLA2G2A PLP1 PTK2 PXN SPP1 TGFB1 THY1 UBC
Entrez ID		550	3685
HPRD ID		03892	01903
Ensembl ID		ENSG00000115307	ENSG00000138448
Uniprot IDs		Q9Y679	L7RXH0 P06756
PDB IDs		2EKF	1JV2 1L5G 1M1X 1U8C 3IJE 4G1E 4G1M 4MMX 4MMY 4MMZ 4O02 4UM8 4UM9 5FFG 5FFO 5NEM 5NER 5NET 5NEU 6AVQ 6AVR 6AVU 6DJP 6MK0 6MSL 6MSU 6NAJ 6OM1 6OM2 6UJA 6UJB 6UJC
Enriched GO Terms of Interacting Partners?
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