GPR35 and ZDHHC3

Data Source:
BioGRID (two hybrid)

		GPR35	ZDHHC3
Description		G protein-coupled receptor 35	zinc finger DHHC-type palmitoyltransferase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Membrane Integral Component Of Membrane
	Molecular Function	G Protein-coupled Receptor Activity C-X-C Chemokine Receptor Activity	Palmitoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Protein Homodimerization Activity
	Biological Process	Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Chemokine-mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Neuronal Action Potential	Protein Targeting To Membrane Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Phosphopantetheinylation Peptidyl-L-cysteine S-palmitoylation Protein Palmitoylation Positive Regulation Of Synaptic Transmission, GABAergic TRAIL-activated Apoptotic Signaling Pathway Lipoprotein Localization To Membrane Protein Localization To Plasma Membrane Positive Regulation Of Receptor Localization To Synapse Protein Localization To Photoreceptor Outer Segment
Pathways		Class A/1 (Rhodopsin-like receptors)
Drugs		Furosemide Pyrantel Kynurenic Acid
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 25489960) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Pediatric autoimmune diseases ( 26301688) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403) Ulcerative colitis ( 28067908 21297633)	Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862) Depressive symptom improvement ( 30468137)
Interacting Genes		59 interacting genes: ABHD14A ADGRB1 AIG1 APH1A ATP1A1 ATP2C1 AUP1 B3GAT3 B4GALT2 BNIP1 CANX CD81 CH25H CMTM3 CRHR2 ERGIC3 FLRT1 FTH1 GHITM GJC2 GPR146 GPR161 HLA-A KCNJ4 KDELR1 LSS MCOLN1 MSMO1 NPC1 NSDHL OSTC PLD3 PLLP PLXDC1 PPP1R3F RTN3 RTN4 SCARB1 SDHD SELENOK SLC15A4 SLC2A1 SLC31A2 SLC37A1 SLC37A4 SLC45A4 SLC8A2 SLC9A7 SPART SYNGR2 SYT11 TMEM161A TMEM94 TSPAN7 VPS25 VTI1B YIF1B ZDHHC3 ZFAND1	6 interacting genes: EWSR1 GABRG2 GPR35 NEDD4L SMAD1 UBQLN4
Entrez ID		2859	51304
HPRD ID		16003	15718
Ensembl ID		ENSG00000178623	ENSG00000163812
Uniprot IDs		A8K2J1 B2RA17 Q9HC97	F8W6M3 Q9NYG2
PDB IDs
Enriched GO Terms of Interacting Partners?
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