RNF111 and SMAD7

Data Source:
HPRD (in vivo, in vitro)

		RNF111	SMAD7
Description		ring finger protein 111	SMAD family member 7
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body Protein-containing Complex	Chromatin Fibrillar Center Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Adherens Junction Catenin Complex Protein-containing Complex Heteromeric SMAD Protein Complex
	Molecular Function	Protein Binding SUMO Polymer Binding SMAD Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	DNA Binding Protein Binding Collagen Binding Beta-catenin Binding Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Metal Ion Binding Activin Binding I-SMAD Binding Transcription Regulator Inhibitor Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Pattern Specification Process Protein Ubiquitination Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Global Genome Nucleotide-excision Repair	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Negative Regulation Of T Cell Cytokine Production Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Transcription By Competitive Promoter Binding Protein Deubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Cell Differentiation Negative Regulation Of Ossification Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Peptidyl-serine Phosphorylation Adherens Junction Assembly Response To Laminar Fluid Shear Stress Cellular Protein-containing Complex Localization Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Artery Morphogenesis Protein Stabilization Negative Regulation Of Ubiquitin-protein Transferase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Chondrocyte Proliferation Positive Regulation Of Chondrocyte Hypertrophy Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T-helper 17 Cell Differentiation
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Formation of Incision Complex in GG-NER Antigen processing: Ubiquitination & Proteasome degradation	Signaling by BMP Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription UCH proteinases Ub-specific processing proteases
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Asperger disorder ( 21182207) Atopic dermatitis ( 25865352) Cerebrospinal fluid AB1-42 levels ( 28247064) Metabolite levels ( 22916037) Social communication problems ( 24047820)	Asthma ( 32296059) Atrial fibrillation ( 30061737 29892015) Colorectal cancer ( 25990418 18372901 18372905 30529582 21761138 17934461 26151821 29228715 30104761 24836286 29471430 24448986 31826910 23266556) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 33020668) Creatinine levels ( 29403010) Dental caries ( 23064961) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163 31015462 30604766) Glomerular filtration rate ( 29403010) Heel bone mineral density ( 30598549) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 23128233) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Parental longevity (at least one long-lived parent) ( 27816938) Red blood cell count ( 32888494 27863252)
Interacting Genes		54 interacting genes: ACTN3 ANAPC11 AP2M1 AXIN1 CREB1 CREBBP CSNK2A1 CTBP1 DTX3L EDARADD KRTAP1-1 KRTAP5-9 LCE4A LRSAM1 MARCHF7 MDFI MVP NBPF19 NOTCH2NLA PAX6 PHF7 PML PSME3 PTPN3 SDCBP2 SMAD3 SMAD6 SMAD7 SMURF2 SUMO1 SUMO2 SUMO3 TRAF5 TRIM21 TRIM8 TSG101 TSPYL1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2M UBE2N UBE2Q2 UBE2V1 UBE2W VAPB	59 interacting genes: ACVR1B AKT1 ASH1L AXIN1 AXIN2 BMPR1B CBL CTNNB1 CXXC5 DVL1 EP300 ERBIN HAT1 HEYL KDM2A MAP2K3 MAP2K6 MAP3K7 MAPK14 MBD1 MRTFB MYOD1 NEDD4L OTUD1 PARD3 PIAS1 PIAS4 RLIM RNF111 SASH3 SETD7 SIRT1 SMAD2 SMAD3 SMAD4 SMAD6 SMURF1 SMURF2 SOX13 SOX5 SOX7 STAMBP STAMBPL1 STRAP TAB1 TGFB1I1 TGFBR1 TGFBR2 TTF1 TTF2 UBE2L3 UCHL5 WWP2 XRCC6 YAP1 ZBTB11 ZBTB44 ZEB1 ZNF107
Entrez ID		54778	4092
HPRD ID		09318	04241
Ensembl ID		ENSG00000157450	ENSG00000101665
Uniprot IDs		A0A024R5T5 Q6ZNA4	B3KYA8 O15105
PDB IDs		2KIZ 5LG0 5LG7	2DJY 2KXQ 2LTV 2LTW 2LTX 2LTY 2LTZ
Enriched GO Terms of Interacting Partners?
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