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RNF111 and SUMO3
Data Source:
BioGRID
(pull down)
RNF111
SUMO3
Description
ring finger protein 111
small ubiquitin like modifier 3
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
PML Body
Protein-containing Complex
Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
PML Body
Molecular Function
Protein Binding
SUMO Polymer Binding
SMAD Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Protein Binding
Protein Tag
Ubiquitin-like Protein Ligase Binding
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Pattern Specification Process
Protein Ubiquitination
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Ubiquitin-dependent SMAD Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Global Genome Nucleotide-excision Repair
Protein Sumoylation
Negative Regulation Of DNA Binding
Regulation Of Protein Localization To Nucleus
Pathways
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Formation of Incision Complex in GG-NER
Antigen processing: Ubiquitination & Proteasome degradation
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is proteolytically processed
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of transcription cofactors
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of DNA replication proteins
SUMOylation of immune response proteins
Formation of Incision Complex in GG-NER
Drugs
Diseases
GWAS
Apolipoprotein A1 levels (
32203549
)
Asperger disorder (
21182207
)
Atopic dermatitis (
25865352
)
Cerebrospinal fluid AB1-42 levels (
28247064
)
Metabolite levels (
22916037
)
Social communication problems (
24047820
)
Delirium (
29631748
)
Interacting Genes
54 interacting genes:
ACTN3
ANAPC11
AP2M1
AXIN1
CREB1
CREBBP
CSNK2A1
CTBP1
DTX3L
EDARADD
KRTAP1-1
KRTAP5-9
LCE4A
LRSAM1
MARCHF7
MDFI
MVP
NBPF19
NOTCH2NLA
PAX6
PHF7
PML
PSME3
PTPN3
SDCBP2
SMAD3
SMAD6
SMAD7
SMURF2
SUMO1
SUMO2
SUMO3
TRAF5
TRIM21
TRIM8
TSG101
TSPYL1
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G2
UBE2I
UBE2K
UBE2M
UBE2N
UBE2Q2
UBE2V1
UBE2W
VAPB
53 interacting genes:
ANXA7
BLM
CCNE2
CDKN1A
CEBPA
CHAF1A
CUL3
DAXX
EGLN3
FAM221A
FOS
HIPK2
HOMEZ
HSF1
HSF2
JUN
KALRN
MAPKAPK3
PFDN1
PIAS1
PIAS2
PIAS3
PIAS4
PML
RANGAP1
RNF111
RNF8
SAE1
SENP1
SENP2
SENP5
SMN1
SOX10
SOX6
SP100
TDG
TDP2
TK1
TP53BP2
TTR
UBA2
UBE2I
UBE3A
UPF2
USP25
USPL1
VIM
WWTR1
YAP1
ZBTB33
ZBTB39
ZCCHC12
ZNF496
Entrez ID
54778
6612
HPRD ID
09318
03754
Ensembl ID
ENSG00000157450
ENSG00000184900
Uniprot IDs
A0A024R5T5
Q6ZNA4
P55854
PDB IDs
2KIZ
5LG0
5LG7
1U4A
2IO1
2MP2
6K5R
6NNQ
Enriched GO Terms of Interacting Partners
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